Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1, MET and ANLN.

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Detalles Bibliográficos
Autores principales:	Hao Huang, Jianyang Hu, Alishba Maryam, Qinghua Huang, Yuchen Zhang, Saravanan Ramakrishnan, Jingyu Li, Haiying Ma, Victor W. S. Ma, Wah Cheuk, Grace Y. K. So, Wei Wang, William C. S. Cho, Liang Zhang, Kui Ming Chan, Xin Wang, Y. Rebecca Chin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abbe2a31ae264afda36fe681ddcc9d63
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spelling	oai:doaj.org-article:abbe2a31ae264afda36fe681ddcc9d632021-12-02T14:25:16ZDefining super-enhancer landscape in triple-negative breast cancer by multiomic profiling10.1038/s41467-021-22445-02041-1723https://doaj.org/article/abbe2a31ae264afda36fe681ddcc9d632021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22445-0https://doaj.org/toc/2041-1723Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1, MET and ANLN.Hao HuangJianyang HuAlishba MaryamQinghua HuangYuchen ZhangSaravanan RamakrishnanJingyu LiHaiying MaVictor W. S. MaWah CheukGrace Y. K. SoWei WangWilliam C. S. ChoLiang ZhangKui Ming ChanXin WangY. Rebecca ChinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Huang Jianyang Hu Alishba Maryam Qinghua Huang Yuchen Zhang Saravanan Ramakrishnan Jingyu Li Haiying Ma Victor W. S. Ma Wah Cheuk Grace Y. K. So Wei Wang William C. S. Cho Liang Zhang Kui Ming Chan Xin Wang Y. Rebecca Chin Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
description	Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognostic outcomes. Here the authors characterize super-enhancer heterogeneity and they identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1, MET and ANLN.
format	article
author	Hao Huang Jianyang Hu Alishba Maryam Qinghua Huang Yuchen Zhang Saravanan Ramakrishnan Jingyu Li Haiying Ma Victor W. S. Ma Wah Cheuk Grace Y. K. So Wei Wang William C. S. Cho Liang Zhang Kui Ming Chan Xin Wang Y. Rebecca Chin
author_facet	Hao Huang Jianyang Hu Alishba Maryam Qinghua Huang Yuchen Zhang Saravanan Ramakrishnan Jingyu Li Haiying Ma Victor W. S. Ma Wah Cheuk Grace Y. K. So Wei Wang William C. S. Cho Liang Zhang Kui Ming Chan Xin Wang Y. Rebecca Chin
author_sort	Hao Huang
title	Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
title_short	Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
title_full	Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
title_fullStr	Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
title_full_unstemmed	Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
title_sort	defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abbe2a31ae264afda36fe681ddcc9d63
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Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

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