The old and new therapeutic approaches to the treatment of giardiasis: Where are we?

Haendel GNO Busatti1, Joseph FG Santos2, Maria A Gomes11Departmento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil; 2Hospital Santa Casa de Miseric&oacute;rdia de Belo Horizonte, Minas Gerais, BrasilAbstract: Giardia lamblia is the causative agent of giar...

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Autores principales:	Haendel GNO Busatti, Joseph FG Santos, Maria A Gomes
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/abc145b369614188852be0c27c4bba9c
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spelling	oai:doaj.org-article:abc145b369614188852be0c27c4bba9c2021-12-02T04:40:33ZThe old and new therapeutic approaches to the treatment of giardiasis: Where are we?1177-54751177-5491https://doaj.org/article/abc145b369614188852be0c27c4bba9c2009-06-01T00:00:00Zhttp://www.dovepress.com/the-old-and-new-therapeutic-approaches-to-the-treatment-of-giardiasis--a3230https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Haendel GNO Busatti1, Joseph FG Santos2, Maria A Gomes11Departmento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil; 2Hospital Santa Casa de Miseric&oacute;rdia de Belo Horizonte, Minas Gerais, BrasilAbstract: Giardia lamblia is the causative agent of giardiasis, one of the most common parasitic infections of the human intestinal tract. This disease most frequently affects children causing abdominal pain, nausea, vomiting, acute or chronic diarrhea, and malabsorption syndrome. In undernourished children, giardiasis is a determining factor in retarded physical and mental development. Antigiardial chemotherapy focuses on the trophozoite stage. Metronidazole and other nitroimidazoles have been used for decades as the therapy of choice against giardiasis. In recent years many other drugs have been proposed for the treatment of giardiasis. Therefore, several synthetic and natural substances have been tested in search of new giardicidal compounds. This study is a review of drugs used in in vitro and in vivo tests, and also drugs tested in clinical trials (nonrandomized and randomized).Keywords: Giardia lamblia; treatment; new drugs Haendel GNO BusattiJoseph FG SantosMaria A GomesDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2009, Iss default, Pp 273-287 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Haendel GNO Busatti Joseph FG Santos Maria A Gomes The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
description	Haendel GNO Busatti1, Joseph FG Santos2, Maria A Gomes11Departmento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil; 2Hospital Santa Casa de Miseric&oacute;rdia de Belo Horizonte, Minas Gerais, BrasilAbstract: Giardia lamblia is the causative agent of giardiasis, one of the most common parasitic infections of the human intestinal tract. This disease most frequently affects children causing abdominal pain, nausea, vomiting, acute or chronic diarrhea, and malabsorption syndrome. In undernourished children, giardiasis is a determining factor in retarded physical and mental development. Antigiardial chemotherapy focuses on the trophozoite stage. Metronidazole and other nitroimidazoles have been used for decades as the therapy of choice against giardiasis. In recent years many other drugs have been proposed for the treatment of giardiasis. Therefore, several synthetic and natural substances have been tested in search of new giardicidal compounds. This study is a review of drugs used in in vitro and in vivo tests, and also drugs tested in clinical trials (nonrandomized and randomized).Keywords: Giardia lamblia; treatment; new drugs
format	article
author	Haendel GNO Busatti Joseph FG Santos Maria A Gomes
author_facet	Haendel GNO Busatti Joseph FG Santos Maria A Gomes
author_sort	Haendel GNO Busatti
title	The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
title_short	The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
title_full	The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
title_fullStr	The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
title_full_unstemmed	The old and new therapeutic approaches to the treatment of giardiasis: Where are we?
title_sort	old and new therapeutic approaches to the treatment of giardiasis: where are we?
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/abc145b369614188852be0c27c4bba9c
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The old and new therapeutic approaches to the treatment of giardiasis: Where are we?

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