Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks

DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homologous recombination (HR) and nonhomologous end join...

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Autores principales:	Muwen Kong, Eric C. Greene
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	non homologous end joining (NHEJ) homologous recombination (HR) single-molecule DNA repair optical tweezers (OT) magnetic tweezers Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/abc753da62a74618b4508711a51a7895
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spelling	oai:doaj.org-article:abc753da62a74618b4508711a51a78952021-11-15T05:04:00ZMechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks2296-634X10.3389/fcell.2021.745311https://doaj.org/article/abc753da62a74618b4508711a51a78952021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.745311/fullhttps://doaj.org/toc/2296-634XDNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homologous recombination (HR) and nonhomologous end joining (NHEJ). The complex nature of both pathways, involving a myriad of protein factors functioning in a highly coordinated manner at distinct stages of repair, lend themselves to detailed mechanistic studies using the latest single-molecule techniques. In avoiding ensemble averaging effects inherent to traditional biochemical or genetic methods, single-molecule studies have painted an increasingly detailed picture for every step of the DSB repair processes.Muwen KongEric C. GreeneFrontiers Media S.A.articlenon homologous end joining (NHEJ)homologous recombination (HR)single-moleculeDNA repairoptical tweezers (OT)magnetic tweezersBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non homologous end joining (NHEJ) homologous recombination (HR) single-molecule DNA repair optical tweezers (OT) magnetic tweezers Biology (General) QH301-705.5
spellingShingle	non homologous end joining (NHEJ) homologous recombination (HR) single-molecule DNA repair optical tweezers (OT) magnetic tweezers Biology (General) QH301-705.5 Muwen Kong Eric C. Greene Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
description	DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homologous recombination (HR) and nonhomologous end joining (NHEJ). The complex nature of both pathways, involving a myriad of protein factors functioning in a highly coordinated manner at distinct stages of repair, lend themselves to detailed mechanistic studies using the latest single-molecule techniques. In avoiding ensemble averaging effects inherent to traditional biochemical or genetic methods, single-molecule studies have painted an increasingly detailed picture for every step of the DSB repair processes.
format	article
author	Muwen Kong Eric C. Greene
author_facet	Muwen Kong Eric C. Greene
author_sort	Muwen Kong
title	Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
title_short	Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
title_full	Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
title_fullStr	Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
title_full_unstemmed	Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
title_sort	mechanistic insights from single-molecule studies of repair of double strand breaks
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/abc753da62a74618b4508711a51a7895
work_keys_str_mv	AT muwenkong mechanisticinsightsfromsinglemoleculestudiesofrepairofdoublestrandbreaks AT ericcgreene mechanisticinsightsfromsinglemoleculestudiesofrepairofdoublestrandbreaks
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Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks

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