Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor

Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor

Abstract Ligand-activated signaling through the type 1 insulin-like growth factor receptor (IGF1R) is implicated in many physiological processes ranging from normal human growth to cancer proliferation and metastasis. IGF1R has also emerged as a target for receptor-mediated transcytosis, a transport...

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Autores principales: Joey Sheff, Ping Wang, Ping Xu, Melanie Arbour, Luke Masson, Henk van Faassen, Greg Hussack, Kristin Kemmerich, Eric Brunette, Danica Stanimirovic, Jennifer J. Hill, John Kelly, Feng Ni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/abc8b420f9a841a1ad3480689cc4f109
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