Co-culture of hematopoietic stem/progenitor cells with human osteblasts favours mono/macrophage differentiation at the expense of the erythroid lineage.

Co-culture of hematopoietic stem/progenitor cells with human osteblasts favours mono/macrophage differentiation at the expense of the erythroid lineage.

Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...

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Autores principales: Simona Salati, Gina Lisignoli, Cristina Manferdini, Valentina Pennucci, Roberta Zini, Elisa Bianchi, Ruggiero Norfo, Andrea Facchini, Sergio Ferrari, Rossella Manfredini
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/abca512f19b14cd49d8bcd6128b8b9bb
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