Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease

Abstract Eosinophilia may guide response to inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease (COPD). This study aimed to determine prevalence of eosinophilia and parasitic infestations in these patients. We conducted a prospective cohort study between February...

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Autores principales:	Narongkorn Saiphoklang, Chanya Chomchoey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abcbc4585be949b5b2705e921803ef96
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spelling	oai:doaj.org-article:abcbc4585be949b5b2705e921803ef962021-12-02T16:06:41ZEosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease10.1038/s41598-020-69541-72045-2322https://doaj.org/article/abcbc4585be949b5b2705e921803ef962020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69541-7https://doaj.org/toc/2045-2322Abstract Eosinophilia may guide response to inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease (COPD). This study aimed to determine prevalence of eosinophilia and parasitic infestations in these patients. We conducted a prospective cohort study between February 2019 and January 2020 and screened 107 stable COPD patients. A total of 77 subjects (84.4% men) were included. Age was 73.8 ± 8.9 years. Forced expiratory volume in 1 s was 66.5 ± 25.5%. Smoking history was 25.9 ± 18 pack-years. Comorbidities included cardiovascular disease (57.1%). Respiratory symptoms were assessed by modified Medical Research Council dyspnea score (1.6 ± 0.8), chronic obstructive pulmonary disease Assessment Test score (9.3 ± 4.9), and 6-min walking distance (317.2 ± 135.2 m). Patients with blood eosinophil count at least 100 cells/μL were 79.2% and at least 300 cells/μL were 33.8%. Intestinal parasites were not found. Significant positive correlations were found between high blood eosinophilia and some post-bronchodilator lung function parameters. In conclusion, eosinophilic COPD was not uncommon. No intestinal parasite was found in this population. This study suggests that stool parasite exam might be omitted for routine practice. Clinicaltrials.in.th Number: TCTR20191129002.Narongkorn SaiphoklangChanya ChomchoeyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Narongkorn Saiphoklang Chanya Chomchoey Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
description	Abstract Eosinophilia may guide response to inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease (COPD). This study aimed to determine prevalence of eosinophilia and parasitic infestations in these patients. We conducted a prospective cohort study between February 2019 and January 2020 and screened 107 stable COPD patients. A total of 77 subjects (84.4% men) were included. Age was 73.8 ± 8.9 years. Forced expiratory volume in 1 s was 66.5 ± 25.5%. Smoking history was 25.9 ± 18 pack-years. Comorbidities included cardiovascular disease (57.1%). Respiratory symptoms were assessed by modified Medical Research Council dyspnea score (1.6 ± 0.8), chronic obstructive pulmonary disease Assessment Test score (9.3 ± 4.9), and 6-min walking distance (317.2 ± 135.2 m). Patients with blood eosinophil count at least 100 cells/μL were 79.2% and at least 300 cells/μL were 33.8%. Intestinal parasites were not found. Significant positive correlations were found between high blood eosinophilia and some post-bronchodilator lung function parameters. In conclusion, eosinophilic COPD was not uncommon. No intestinal parasite was found in this population. This study suggests that stool parasite exam might be omitted for routine practice. Clinicaltrials.in.th Number: TCTR20191129002.
format	article
author	Narongkorn Saiphoklang Chanya Chomchoey
author_facet	Narongkorn Saiphoklang Chanya Chomchoey
author_sort	Narongkorn Saiphoklang
title	Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
title_short	Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
title_full	Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
title_fullStr	Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
title_full_unstemmed	Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
title_sort	eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/abcbc4585be949b5b2705e921803ef96
work_keys_str_mv	AT narongkornsaiphoklang eosinophiliaandparasiticinfestationsinpatientswithchronicobstructivepulmonarydisease AT chanyachomchoey eosinophiliaandparasiticinfestationsinpatientswithchronicobstructivepulmonarydisease
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Eosinophilia and parasitic infestations in patients with chronic obstructive pulmonary disease

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