Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2

Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2

Song et al describe and identify monoclonal antibodies that target the SARSCoV-2 Spike protein, including CA521FALA, which demonstrated neutralising potential in vivo and in vitro. They performed structural analysis, which revealed that CA521FALA recognizes an epitope overlapping with angiotensin co...

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Autores principales: Deyong Song, Wenbo Wang, Chuangchuang Dong, Zhenfei Ning, Xiu Liu, Chuan Liu, Guangying Du, Chunjie Sha, Kailin Wang, Jun Lu, Baiping Sun, Yanyan Zhao, Qiaoping Wang, Hongguang Xu, Ying Li, Zhenduo Shen, Jie Jiao, Ruiying Wang, Jingwei Tian, Wanhui Liu, Lan Wang, Yong-Qiang Deng, Changlin Dou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/abce2e8dd92d46c18256f52f67586310
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spelling oai:doaj.org-article:abce2e8dd92d46c18256f52f675863102021-12-02T18:28:59ZStructure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-210.1038/s42003-021-02029-w2399-3642https://doaj.org/article/abce2e8dd92d46c18256f52f675863102021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02029-whttps://doaj.org/toc/2399-3642Song et al describe and identify monoclonal antibodies that target the SARSCoV-2 Spike protein, including CA521FALA, which demonstrated neutralising potential in vivo and in vitro. They performed structural analysis, which revealed that CA521FALA recognizes an epitope overlapping with angiotensin converting enzyme 2 (ACE2)-binding sites in SARS-CoV-2 Spike protein therefore making it a promising therapeutic antibody.Deyong SongWenbo WangChuangchuang DongZhenfei NingXiu LiuChuan LiuGuangying DuChunjie ShaKailin WangJun LuBaiping SunYanyan ZhaoQiaoping WangHongguang XuYing LiZhenduo ShenJie JiaoRuiying WangJingwei TianWanhui LiuLan WangYong-Qiang DengChanglin DouNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Deyong Song
Wenbo Wang
Chuangchuang Dong
Zhenfei Ning
Xiu Liu
Chuan Liu
Guangying Du
Chunjie Sha
Kailin Wang
Jun Lu
Baiping Sun
Yanyan Zhao
Qiaoping Wang
Hongguang Xu
Ying Li
Zhenduo Shen
Jie Jiao
Ruiying Wang
Jingwei Tian
Wanhui Liu
Lan Wang
Yong-Qiang Deng
Changlin Dou
Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
description Song et al describe and identify monoclonal antibodies that target the SARSCoV-2 Spike protein, including CA521FALA, which demonstrated neutralising potential in vivo and in vitro. They performed structural analysis, which revealed that CA521FALA recognizes an epitope overlapping with angiotensin converting enzyme 2 (ACE2)-binding sites in SARS-CoV-2 Spike protein therefore making it a promising therapeutic antibody.
format article
author Deyong Song
Wenbo Wang
Chuangchuang Dong
Zhenfei Ning
Xiu Liu
Chuan Liu
Guangying Du
Chunjie Sha
Kailin Wang
Jun Lu
Baiping Sun
Yanyan Zhao
Qiaoping Wang
Hongguang Xu
Ying Li
Zhenduo Shen
Jie Jiao
Ruiying Wang
Jingwei Tian
Wanhui Liu
Lan Wang
Yong-Qiang Deng
Changlin Dou
author_facet Deyong Song
Wenbo Wang
Chuangchuang Dong
Zhenfei Ning
Xiu Liu
Chuan Liu
Guangying Du
Chunjie Sha
Kailin Wang
Jun Lu
Baiping Sun
Yanyan Zhao
Qiaoping Wang
Hongguang Xu
Ying Li
Zhenduo Shen
Jie Jiao
Ruiying Wang
Jingwei Tian
Wanhui Liu
Lan Wang
Yong-Qiang Deng
Changlin Dou
author_sort Deyong Song
title Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
title_short Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
title_full Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
title_fullStr Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
title_full_unstemmed Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
title_sort structure and function analysis of a potent human neutralizing antibody ca521fala against sars-cov-2
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/abce2e8dd92d46c18256f52f67586310
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