Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

Targeting the adenosinergic pathway represents a therapeutic option to overcome tumor-induced immunosuppression. Here the authors design E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune re...

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Autores principales: Jing Qi, Feiyang Jin, Yuchan You, Yan Du, Di Liu, Xiaoling Xu, Jun Wang, Luwen Zhu, Minjiang Chen, Gaofeng Shu, Liming Wu, Jiansong Ji, Yongzhong Du
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/abce4ae1a7124d5ebad9a32c2e0500b4
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Sumario:Targeting the adenosinergic pathway represents a therapeutic option to overcome tumor-induced immunosuppression. Here the authors design E-selectin-modified thermal-sensitive micelles loaded with doxorubicin and an adenosine A2 receptor antagonist to enhance chemotherapy-induced anti-tumor immune responses.