A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption

Abstract Using a new method for measuring the molecular ratio (R) of inhalation to exhalation, we investigated the effect of high fraction of inspired oxygen (FIO2) on oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ) in mechanically ventilated rats. Twelve ra...

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Autores principales:	Koichiro Shinozaki, Yu Okuma, Kota Saeki, Santiago J. Miyara, Tomoaki Aoki, Ernesto P. Molmenti, Tai Yin, Junhwan Kim, Joshua W. Lampe, Lance B. Becker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abcf48b6073242daae3506e4ed84afa0
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spelling	oai:doaj.org-article:abcf48b6073242daae3506e4ed84afa02021-12-02T17:41:27ZA method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption10.1038/s41598-021-91246-82045-2322https://doaj.org/article/abcf48b6073242daae3506e4ed84afa02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91246-8https://doaj.org/toc/2045-2322Abstract Using a new method for measuring the molecular ratio (R) of inhalation to exhalation, we investigated the effect of high fraction of inspired oxygen (FIO2) on oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ) in mechanically ventilated rats. Twelve rats were equally assigned into two groups by anesthetics: intravenous midazolam/fentanyl vs. inhaled isoflurane. R, VO2, VCO2, and RQ were measured at FIO2 0.3 or 1.0. R error was ± 0.003. R was 1.0099 ± 0.0023 with isoflurane and 1.0074 ± 0.0018 with midazolam/fentanyl. R was 1.0081 ± 0.0017 at an FIO2 of 0.3 and 1.0092 ± 0.0029 at an FIO2 of 1.0. There were no differences in VCO2 among the groups. VO2 increased at FIO2 1.0, which was more notable when midazolam/fentanyl was used (isoflurane-FIO2 0.3: 15.4 ± 1.1; isoflurane-FIO2 1.0: 17.2 ± 1.8; midazolam/fentanyl-FIO2 0.3: 15.4 ± 1.1; midazolam/fentanyl-FIO2 1.0: 21.0 ± 2.2 mL/kg/min at STP). The RQ was lower at FIO2 1.0 than FIO2 0.3 (isoflurane-FIO2 0.3: 0.80 ± 0.07; isoflurane-FIO2 1.0: 0.71 ± 0.05; midazolam/fentanyl-FIO2 0.3: 0.79 ± 0.03; midazolam/fentanyl-FIO2 1.0: 0.59 ± 0.04). R was not affected by either anesthetics or FIO2. Inspired 100% O2 increased VO2 and decreased RQ, which might be more remarkable when midazolam/fentanyl was used.Koichiro ShinozakiYu OkumaKota SaekiSantiago J. MiyaraTomoaki AokiErnesto P. MolmentiTai YinJunhwan KimJoshua W. LampeLance B. BeckerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koichiro Shinozaki Yu Okuma Kota Saeki Santiago J. Miyara Tomoaki Aoki Ernesto P. Molmenti Tai Yin Junhwan Kim Joshua W. Lampe Lance B. Becker A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
description	Abstract Using a new method for measuring the molecular ratio (R) of inhalation to exhalation, we investigated the effect of high fraction of inspired oxygen (FIO2) on oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ) in mechanically ventilated rats. Twelve rats were equally assigned into two groups by anesthetics: intravenous midazolam/fentanyl vs. inhaled isoflurane. R, VO2, VCO2, and RQ were measured at FIO2 0.3 or 1.0. R error was ± 0.003. R was 1.0099 ± 0.0023 with isoflurane and 1.0074 ± 0.0018 with midazolam/fentanyl. R was 1.0081 ± 0.0017 at an FIO2 of 0.3 and 1.0092 ± 0.0029 at an FIO2 of 1.0. There were no differences in VCO2 among the groups. VO2 increased at FIO2 1.0, which was more notable when midazolam/fentanyl was used (isoflurane-FIO2 0.3: 15.4 ± 1.1; isoflurane-FIO2 1.0: 17.2 ± 1.8; midazolam/fentanyl-FIO2 0.3: 15.4 ± 1.1; midazolam/fentanyl-FIO2 1.0: 21.0 ± 2.2 mL/kg/min at STP). The RQ was lower at FIO2 1.0 than FIO2 0.3 (isoflurane-FIO2 0.3: 0.80 ± 0.07; isoflurane-FIO2 1.0: 0.71 ± 0.05; midazolam/fentanyl-FIO2 0.3: 0.79 ± 0.03; midazolam/fentanyl-FIO2 1.0: 0.59 ± 0.04). R was not affected by either anesthetics or FIO2. Inspired 100% O2 increased VO2 and decreased RQ, which might be more remarkable when midazolam/fentanyl was used.
format	article
author	Koichiro Shinozaki Yu Okuma Kota Saeki Santiago J. Miyara Tomoaki Aoki Ernesto P. Molmenti Tai Yin Junhwan Kim Joshua W. Lampe Lance B. Becker
author_facet	Koichiro Shinozaki Yu Okuma Kota Saeki Santiago J. Miyara Tomoaki Aoki Ernesto P. Molmenti Tai Yin Junhwan Kim Joshua W. Lampe Lance B. Becker
author_sort	Koichiro Shinozaki
title	A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
title_short	A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
title_full	A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
title_fullStr	A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
title_full_unstemmed	A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
title_sort	method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abcf48b6073242daae3506e4ed84afa0
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A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption

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