Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans

Abstract During their life, crustaceans undergo several molts, which if theoretically compared to the human body would be equivalent to replacing all bones at a single event. Such a dramatic repetitive event is coupled to unique molecular mechanisms of mineralization so far mostly unknown. Unlike hu...

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Autores principales:	Shai Abehsera, Shmuel Bentov, Xuguang Li, Simy Weil, Rivka Manor, Shahar Sagi, Shihao Li, Fuhua Li, Isam Khalaila, Eliahu D. Aflalo, Amir Sagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abcf6c6ce4584373acdfcc8b22626275
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spelling	oai:doaj.org-article:abcf6c6ce4584373acdfcc8b226262752021-12-02T15:02:23ZGenes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans10.1038/s41598-021-91155-w2045-2322https://doaj.org/article/abcf6c6ce4584373acdfcc8b226262752021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91155-whttps://doaj.org/toc/2045-2322Abstract During their life, crustaceans undergo several molts, which if theoretically compared to the human body would be equivalent to replacing all bones at a single event. Such a dramatic repetitive event is coupled to unique molecular mechanisms of mineralization so far mostly unknown. Unlike human bone mineralized with calcium phosphate, the crustacean exoskeleton is mineralized mainly by calcium carbonate. Crustacean growth thus necessitates well-timed mobilization of bicarbonate to specific extracellular sites of biomineralization at distinct molt cycle stages. Here, by looking at the crayfish Cherax quadricarinatus at different molting stages, we suggest that the mechanisms of bicarbonate ion transport for mineralization in crustaceans involve the SLC4 family of transporters and that these proteins play a key role in the tight coupling between molt cycle events and mineral deposition. This discovery of putative bicarbonate transporters in a pancrustacean with functional genomic evidence from genes encoding the SLC4 family—mostly known for their role in pH control—is discussed in the context of the evolution of calcium carbonate biomineralization.Shai AbehseraShmuel BentovXuguang LiSimy WeilRivka ManorShahar SagiShihao LiFuhua LiIsam KhalailaEliahu D. AflaloAmir SagiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shai Abehsera Shmuel Bentov Xuguang Li Simy Weil Rivka Manor Shahar Sagi Shihao Li Fuhua Li Isam Khalaila Eliahu D. Aflalo Amir Sagi Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
description	Abstract During their life, crustaceans undergo several molts, which if theoretically compared to the human body would be equivalent to replacing all bones at a single event. Such a dramatic repetitive event is coupled to unique molecular mechanisms of mineralization so far mostly unknown. Unlike human bone mineralized with calcium phosphate, the crustacean exoskeleton is mineralized mainly by calcium carbonate. Crustacean growth thus necessitates well-timed mobilization of bicarbonate to specific extracellular sites of biomineralization at distinct molt cycle stages. Here, by looking at the crayfish Cherax quadricarinatus at different molting stages, we suggest that the mechanisms of bicarbonate ion transport for mineralization in crustaceans involve the SLC4 family of transporters and that these proteins play a key role in the tight coupling between molt cycle events and mineral deposition. This discovery of putative bicarbonate transporters in a pancrustacean with functional genomic evidence from genes encoding the SLC4 family—mostly known for their role in pH control—is discussed in the context of the evolution of calcium carbonate biomineralization.
format	article
author	Shai Abehsera Shmuel Bentov Xuguang Li Simy Weil Rivka Manor Shahar Sagi Shihao Li Fuhua Li Isam Khalaila Eliahu D. Aflalo Amir Sagi
author_facet	Shai Abehsera Shmuel Bentov Xuguang Li Simy Weil Rivka Manor Shahar Sagi Shihao Li Fuhua Li Isam Khalaila Eliahu D. Aflalo Amir Sagi
author_sort	Shai Abehsera
title	Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
title_short	Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
title_full	Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
title_fullStr	Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
title_full_unstemmed	Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
title_sort	genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abcf6c6ce4584373acdfcc8b22626275
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Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans

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