Major Depression Impairs the Use of Reward Values for Decision-Making

Abstract Depression is a debilitating condition with a high prevalence. Depressed patients have been shown to be diminished in their ability to integrate their reinforcement history to adjust future behaviour during instrumental reward learning tasks. Here, we tested whether such impairments could a...

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Autores principales:	Samuel Rupprechter, Aistis Stankevicius, Quentin J. M. Huys, J. Douglas Steele, Peggy Seriès
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Fractional Stimuli Reward Probability Pavlovian Conditioning Task Pilot Dataset Leaky Model Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abd17d754e1743dea3b72dfc1464a2e8
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spelling	oai:doaj.org-article:abd17d754e1743dea3b72dfc1464a2e82021-12-02T15:08:22ZMajor Depression Impairs the Use of Reward Values for Decision-Making10.1038/s41598-018-31730-w2045-2322https://doaj.org/article/abd17d754e1743dea3b72dfc1464a2e82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31730-whttps://doaj.org/toc/2045-2322Abstract Depression is a debilitating condition with a high prevalence. Depressed patients have been shown to be diminished in their ability to integrate their reinforcement history to adjust future behaviour during instrumental reward learning tasks. Here, we tested whether such impairments could also be observed in a Pavlovian conditioning task. We recruited and analysed 32 subjects, 15 with depression and 17 healthy controls, to study behavioural group differences in learning and decision-making. Participants had to estimate the probability of some fractal stimuli to be associated with a binary reward, based on a few passive observations. They then had to make a choice between one of the observed fractals and another target for which the reward probability was explicitly given. Computational modelling was used to succinctly describe participants’ behaviour. Patients performed worse than controls at the task. Computational modelling revealed that this was caused by behavioural impairments during both learning and decision phases. Depressed subjects showed lower memory of observed rewards and had an impaired ability to use internal value estimations to guide decision-making in our task.Samuel RupprechterAistis StankeviciusQuentin J. M. HuysJ. Douglas SteelePeggy SerièsNature PortfolioarticleFractional StimuliReward ProbabilityPavlovian Conditioning TaskPilot DatasetLeaky ModelMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fractional Stimuli Reward Probability Pavlovian Conditioning Task Pilot Dataset Leaky Model Medicine R Science Q
spellingShingle	Fractional Stimuli Reward Probability Pavlovian Conditioning Task Pilot Dataset Leaky Model Medicine R Science Q Samuel Rupprechter Aistis Stankevicius Quentin J. M. Huys J. Douglas Steele Peggy Seriès Major Depression Impairs the Use of Reward Values for Decision-Making
description	Abstract Depression is a debilitating condition with a high prevalence. Depressed patients have been shown to be diminished in their ability to integrate their reinforcement history to adjust future behaviour during instrumental reward learning tasks. Here, we tested whether such impairments could also be observed in a Pavlovian conditioning task. We recruited and analysed 32 subjects, 15 with depression and 17 healthy controls, to study behavioural group differences in learning and decision-making. Participants had to estimate the probability of some fractal stimuli to be associated with a binary reward, based on a few passive observations. They then had to make a choice between one of the observed fractals and another target for which the reward probability was explicitly given. Computational modelling was used to succinctly describe participants’ behaviour. Patients performed worse than controls at the task. Computational modelling revealed that this was caused by behavioural impairments during both learning and decision phases. Depressed subjects showed lower memory of observed rewards and had an impaired ability to use internal value estimations to guide decision-making in our task.
format	article
author	Samuel Rupprechter Aistis Stankevicius Quentin J. M. Huys J. Douglas Steele Peggy Seriès
author_facet	Samuel Rupprechter Aistis Stankevicius Quentin J. M. Huys J. Douglas Steele Peggy Seriès
author_sort	Samuel Rupprechter
title	Major Depression Impairs the Use of Reward Values for Decision-Making
title_short	Major Depression Impairs the Use of Reward Values for Decision-Making
title_full	Major Depression Impairs the Use of Reward Values for Decision-Making
title_fullStr	Major Depression Impairs the Use of Reward Values for Decision-Making
title_full_unstemmed	Major Depression Impairs the Use of Reward Values for Decision-Making
title_sort	major depression impairs the use of reward values for decision-making
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/abd17d754e1743dea3b72dfc1464a2e8
work_keys_str_mv	AT samuelrupprechter majordepressionimpairstheuseofrewardvaluesfordecisionmaking AT aistisstankevicius majordepressionimpairstheuseofrewardvaluesfordecisionmaking AT quentinjmhuys majordepressionimpairstheuseofrewardvaluesfordecisionmaking AT jdouglassteele majordepressionimpairstheuseofrewardvaluesfordecisionmaking AT peggyseries majordepressionimpairstheuseofrewardvaluesfordecisionmaking
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Major Depression Impairs the Use of Reward Values for Decision-Making

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