Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were colle...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2021
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oai:doaj.org-article:abd2463b7913495b957bfda3159ff2f62021-11-23T17:18:51ZClinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study10.17305/bjbms.2021.65771512-86011840-4812https://doaj.org/article/abd2463b7913495b957bfda3159ff2f62021-11-01T00:00:00Zhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/6577https://doaj.org/toc/1512-8601https://doaj.org/toc/1840-4812 The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin, and international normalized ratio (INR) levels were recorded on the 1st, 5th, and 10th days of hospitalization in order to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8±10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (13%), liver failure (21%), ARDS (85%), acute kidney injury (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension, diabetes mellitus, use of acetylsalicylic acid (ASA) or low molecular weight heparin (LMWH), hemoglobin, D-dimer, INR, and acute kidney injury were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications. Gokhan AliciHasan Ali BarmanRamazan AsogluAdem AticiAtike Nazli AkcigerOmer SitOmer DoganYucel YavuzSongul BorahanOmer GencBaris GungorAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaarticleMajor bleedingCOVID-19mortalityacute respiratory distress syndromecardiac injuryMedicine (General)R5-920ENBosnian Journal of Basic Medical Sciences (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Major bleeding COVID-19 mortality acute respiratory distress syndrome cardiac injury Medicine (General) R5-920 |
| spellingShingle |
Major bleeding COVID-19 mortality acute respiratory distress syndrome cardiac injury Medicine (General) R5-920 Gokhan Alici Hasan Ali Barman Ramazan Asoglu Adem Atici Atike Nazli Akciger Omer Sit Omer Dogan Yucel Yavuz Songul Borahan Omer Genc Baris Gungor Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| description |
The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin, and international normalized ratio (INR) levels were recorded on the 1st, 5th, and 10th days of hospitalization in order to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8±10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (13%), liver failure (21%), ARDS (85%), acute kidney injury (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension, diabetes mellitus, use of acetylsalicylic acid (ASA) or low molecular weight heparin (LMWH), hemoglobin, D-dimer, INR, and acute kidney injury were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications.
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| format |
article |
| author |
Gokhan Alici Hasan Ali Barman Ramazan Asoglu Adem Atici Atike Nazli Akciger Omer Sit Omer Dogan Yucel Yavuz Songul Borahan Omer Genc Baris Gungor |
| author_facet |
Gokhan Alici Hasan Ali Barman Ramazan Asoglu Adem Atici Atike Nazli Akciger Omer Sit Omer Dogan Yucel Yavuz Songul Borahan Omer Genc Baris Gungor |
| author_sort |
Gokhan Alici |
| title |
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_short |
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_full |
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_fullStr |
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_full_unstemmed |
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_sort |
clinical features and major bleeding predictors for 161 fatal cases of covid-19: a retrospective observational study |
| publisher |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| publishDate |
2021 |
| url |
https://doaj.org/article/abd2463b7913495b957bfda3159ff2f6 |
| work_keys_str_mv |
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