High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression

ABSTRACT Environmental stresses often co-occur when bacteria encounter antibiotic treatment inside the human body. The cellular response to environmental stressors can alter the global gene expression pattern of bacteria. However, the relationship between the cellular stress response and antibiotic...

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Autores principales:	Manlu Zhu, Xiongfeng Dai
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	antibiotic susceptibility cross-protection efflux pumps high salt Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/abd292f449ca4e6ca8770d0149ee3b8f
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spelling	oai:doaj.org-article:abd292f449ca4e6ca8770d0149ee3b8f2021-11-15T15:22:14ZHigh Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression10.1128/mSphere.00095-182379-5042https://doaj.org/article/abd292f449ca4e6ca8770d0149ee3b8f2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00095-18https://doaj.org/toc/2379-5042ABSTRACT Environmental stresses often co-occur when bacteria encounter antibiotic treatment inside the human body. The cellular response to environmental stressors can alter the global gene expression pattern of bacteria. However, the relationship between the cellular stress response and antibiotic susceptibility remains poorly understood. Here we studied the effect of high salt, an important environmental stress condition inside the human body, on bacterial susceptibility to antibiotics. We found that high salt reduces the susceptibility of Escherichia coli to tetracycline and chloramphenicol, leading to a cross-protection effect. The cross-protection effect originates from the increased AcrAB-TolC efflux pump expression level under high-salt conditions. Our study demonstrates that stress-induced gene expression alterations can cross-protect bacteria from antibiotic treatment and should thus be considered when investigating antibiotic susceptibility and applying antimicrobial treatment. IMPORTANCE Environmental stresses often co-occur when bacteria confront antibiotic treatment. We provide a clear example that a natural stress condition (high salt) can cross-protect bacteria from antibiotic treatment by triggering the bacterial stress response program (elevated AcrAB-TolC efflux pump expression). Our study highlights the importance of taking the co-occurrence of bacterial environmental stresses into consideration when investigating antibiotic susceptibility and applying antimicrobial treatment.Manlu ZhuXiongfeng DaiAmerican Society for Microbiologyarticleantibiotic susceptibilitycross-protectionefflux pumpshigh saltMicrobiologyQR1-502ENmSphere, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic susceptibility cross-protection efflux pumps high salt Microbiology QR1-502
spellingShingle	antibiotic susceptibility cross-protection efflux pumps high salt Microbiology QR1-502 Manlu Zhu Xiongfeng Dai High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression
description	ABSTRACT Environmental stresses often co-occur when bacteria encounter antibiotic treatment inside the human body. The cellular response to environmental stressors can alter the global gene expression pattern of bacteria. However, the relationship between the cellular stress response and antibiotic susceptibility remains poorly understood. Here we studied the effect of high salt, an important environmental stress condition inside the human body, on bacterial susceptibility to antibiotics. We found that high salt reduces the susceptibility of Escherichia coli to tetracycline and chloramphenicol, leading to a cross-protection effect. The cross-protection effect originates from the increased AcrAB-TolC efflux pump expression level under high-salt conditions. Our study demonstrates that stress-induced gene expression alterations can cross-protect bacteria from antibiotic treatment and should thus be considered when investigating antibiotic susceptibility and applying antimicrobial treatment. IMPORTANCE Environmental stresses often co-occur when bacteria confront antibiotic treatment. We provide a clear example that a natural stress condition (high salt) can cross-protect bacteria from antibiotic treatment by triggering the bacterial stress response program (elevated AcrAB-TolC efflux pump expression). Our study highlights the importance of taking the co-occurrence of bacterial environmental stresses into consideration when investigating antibiotic susceptibility and applying antimicrobial treatment.
format	article
author	Manlu Zhu Xiongfeng Dai
author_facet	Manlu Zhu Xiongfeng Dai
author_sort	Manlu Zhu
title	High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression
title_short	High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression
title_full	High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression
title_fullStr	High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression
title_full_unstemmed	High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression
title_sort	high salt cross-protects <named-content content-type="genus-species">escherichia coli</named-content> from antibiotic treatment through increasing efflux pump expression
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/abd292f449ca4e6ca8770d0149ee3b8f
work_keys_str_mv	AT manluzhu highsaltcrossprotectsnamedcontentcontenttypegenusspeciesescherichiacolinamedcontentfromantibiotictreatmentthroughincreasingeffluxpumpexpression AT xiongfengdai highsaltcrossprotectsnamedcontentcontenttypegenusspeciesescherichiacolinamedcontentfromantibiotictreatmentthroughincreasingeffluxpumpexpression
_version_	1718428024623333376

High Salt Cross-Protects <named-content content-type="genus-species">Escherichia coli</named-content> from Antibiotic Treatment through Increasing Efflux Pump Expression

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