Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology...
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2021
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oai:doaj.org-article:abd4416e3b5443348ab2e3eda956339c2021-11-25T18:57:56ZAntibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–202110.3390/s212276141424-8220https://doaj.org/article/abd4416e3b5443348ab2e3eda956339c2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7614https://doaj.org/toc/1424-8220The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use.Natalia RudenkoKsenia FursovaAnna ShepelyakovskayaAnna KaratovskayaFedor BrovkoMDPI AGarticleimmunosensorsmonoclonal antibodiesrecombinant antibodiesprotein scaffoldslateral flow immunoassaymultiplex test systemsChemical technologyTP1-1185ENSensors, Vol 21, Iss 7614, p 7614 (2021) |
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immunosensors monoclonal antibodies recombinant antibodies protein scaffolds lateral flow immunoassay multiplex test systems Chemical technology TP1-1185 |
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immunosensors monoclonal antibodies recombinant antibodies protein scaffolds lateral flow immunoassay multiplex test systems Chemical technology TP1-1185 Natalia Rudenko Ksenia Fursova Anna Shepelyakovskaya Anna Karatovskaya Fedor Brovko Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 |
| description |
The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use. |
| format |
article |
| author |
Natalia Rudenko Ksenia Fursova Anna Shepelyakovskaya Anna Karatovskaya Fedor Brovko |
| author_facet |
Natalia Rudenko Ksenia Fursova Anna Shepelyakovskaya Anna Karatovskaya Fedor Brovko |
| author_sort |
Natalia Rudenko |
| title |
Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 |
| title_short |
Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 |
| title_full |
Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 |
| title_fullStr |
Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 |
| title_full_unstemmed |
Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021 |
| title_sort |
antibodies as biosensors’ key components: state-of-the-art in russia 2020–2021 |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/abd4416e3b5443348ab2e3eda956339c |
| work_keys_str_mv |
AT nataliarudenko antibodiesasbiosensorskeycomponentsstateoftheartinrussia20202021 AT kseniafursova antibodiesasbiosensorskeycomponentsstateoftheartinrussia20202021 AT annashepelyakovskaya antibodiesasbiosensorskeycomponentsstateoftheartinrussia20202021 AT annakaratovskaya antibodiesasbiosensorskeycomponentsstateoftheartinrussia20202021 AT fedorbrovko antibodiesasbiosensorskeycomponentsstateoftheartinrussia20202021 |
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