Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment

4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-component procedure. Moreover, the...

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Autores principales:	Cebeci Yıldız Uygun, Karaoğlu Şengül Alpay
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	1,2,4-triazole fluoroquinolone conazole antimicrobial activity Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/abd6be9e8cdb4c8db69da53ffb4c328b
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spelling	oai:doaj.org-article:abd6be9e8cdb4c8db69da53ffb4c328b2021-12-05T14:10:50ZDesign and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment2191-019710.1515/hc-2020-0126https://doaj.org/article/abd6be9e8cdb4c8db69da53ffb4c328b2021-11-01T00:00:00Zhttps://doi.org/10.1515/hc-2020-0126https://doaj.org/toc/2191-01974-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-component procedure. Moreover, the synthesis of six compounds, which can be considered as conazole analogues, was performed starting from 1,2,4-triazole-3-one compounds via three steps by either conventional or microwave-mediated conditions. All the newly synthesized compounds were screened for their antimicrobial activities. Most exhibited good to moderate antibacterial and/or antifungal activity. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, 1H NMR, 13C NMR, and LC-MS) data.Cebeci Yıldız UygunKaraoğlu Şengül AlpayDe Gruyterarticle1,2,4-triazolefluoroquinoloneconazoleantimicrobial activityOrganic chemistryQD241-441ENHeterocyclic Communications, Vol 27, Iss 1, Pp 100-111 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	1,2,4-triazole fluoroquinolone conazole antimicrobial activity Organic chemistry QD241-441
spellingShingle	1,2,4-triazole fluoroquinolone conazole antimicrobial activity Organic chemistry QD241-441 Cebeci Yıldız Uygun Karaoğlu Şengül Alpay Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
description	4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-component procedure. Moreover, the synthesis of six compounds, which can be considered as conazole analogues, was performed starting from 1,2,4-triazole-3-one compounds via three steps by either conventional or microwave-mediated conditions. All the newly synthesized compounds were screened for their antimicrobial activities. Most exhibited good to moderate antibacterial and/or antifungal activity. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, 1H NMR, 13C NMR, and LC-MS) data.
format	article
author	Cebeci Yıldız Uygun Karaoğlu Şengül Alpay
author_facet	Cebeci Yıldız Uygun Karaoğlu Şengül Alpay
author_sort	Cebeci Yıldız Uygun
title	Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
title_short	Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
title_full	Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
title_fullStr	Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
title_full_unstemmed	Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment
title_sort	design and microwave-assisted synthesis of a novel mannich base and conazole derivatives and their biological assessment
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/abd6be9e8cdb4c8db69da53ffb4c328b
work_keys_str_mv	AT cebeciyıldızuygun designandmicrowaveassistedsynthesisofanovelmannichbaseandconazolederivativesandtheirbiologicalassessment AT karaoglusengulalpay designandmicrowaveassistedsynthesisofanovelmannichbaseandconazolederivativesandtheirbiologicalassessment
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Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment

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