Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda
Abstract Infections of the central nervous system (CNS) are severe conditions, leading to neurological sequelae or death. Knowledge of the causative agents is essential to develop guidelines for case management in resource-limited settings. Between August 2009 and October 2012, we conducted a prospe...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/abd7f92eb8454ec8b3543713f73615cc |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:abd7f92eb8454ec8b3543713f73615cc |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:abd7f92eb8454ec8b3543713f73615cc2021-12-02T11:52:21ZAetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda10.1038/s41598-017-02741-w2045-2322https://doaj.org/article/abd7f92eb8454ec8b3543713f73615cc2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02741-whttps://doaj.org/toc/2045-2322Abstract Infections of the central nervous system (CNS) are severe conditions, leading to neurological sequelae or death. Knowledge of the causative agents is essential to develop guidelines for case management in resource-limited settings. Between August 2009 and October 2012, we conducted a prospective descriptive study of the aetiology of suspected CNS infections in children two months to 12 years old, with fever and at least one sign of CNS involvement in Mbarara Hospital, Uganda. Children were clinically evaluated on admission and discharge, and followed-up for 6 months for neurological sequelae. Pathogens were identified from cerebrospinal fluid (CSF) and blood using microbiological and molecular methods. We enrolled 459 children. Plasmodium falciparum (36.2%) and bacteria in CSF (13.3%) or blood (3.3%) were the most detected pathogens. Viruses were found in 27 (5.9%) children. No pathogen was isolated in 207 (45.1%) children. Patterns varied by age and HIV status. Eighty-three (18.1%) children died during hospitalisation, and 23 (5.0%) during follow-up. Forty-one (13.5%) children had neurological sequelae at the last visit. While malaria remains the main aetiology in children with suspected CNS infections, no pathogen was isolated in many children. The high mortality and high rate of neurological sequelae highlight the need for efficient diagnosis.Anne-Laure PageYap Boum IIElizabeth KemigishaNicolas SalezDeborah NanjebeCéline LangendorfSaid AberraneDan NyehanganeFabienne NackersEmmanuel BaronRémi CharrelJuliet Mwanga-AmumpaireNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Anne-Laure Page Yap Boum II Elizabeth Kemigisha Nicolas Salez Deborah Nanjebe Céline Langendorf Said Aberrane Dan Nyehangane Fabienne Nackers Emmanuel Baron Rémi Charrel Juliet Mwanga-Amumpaire Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda |
| description |
Abstract Infections of the central nervous system (CNS) are severe conditions, leading to neurological sequelae or death. Knowledge of the causative agents is essential to develop guidelines for case management in resource-limited settings. Between August 2009 and October 2012, we conducted a prospective descriptive study of the aetiology of suspected CNS infections in children two months to 12 years old, with fever and at least one sign of CNS involvement in Mbarara Hospital, Uganda. Children were clinically evaluated on admission and discharge, and followed-up for 6 months for neurological sequelae. Pathogens were identified from cerebrospinal fluid (CSF) and blood using microbiological and molecular methods. We enrolled 459 children. Plasmodium falciparum (36.2%) and bacteria in CSF (13.3%) or blood (3.3%) were the most detected pathogens. Viruses were found in 27 (5.9%) children. No pathogen was isolated in 207 (45.1%) children. Patterns varied by age and HIV status. Eighty-three (18.1%) children died during hospitalisation, and 23 (5.0%) during follow-up. Forty-one (13.5%) children had neurological sequelae at the last visit. While malaria remains the main aetiology in children with suspected CNS infections, no pathogen was isolated in many children. The high mortality and high rate of neurological sequelae highlight the need for efficient diagnosis. |
| format |
article |
| author |
Anne-Laure Page Yap Boum II Elizabeth Kemigisha Nicolas Salez Deborah Nanjebe Céline Langendorf Said Aberrane Dan Nyehangane Fabienne Nackers Emmanuel Baron Rémi Charrel Juliet Mwanga-Amumpaire |
| author_facet |
Anne-Laure Page Yap Boum II Elizabeth Kemigisha Nicolas Salez Deborah Nanjebe Céline Langendorf Said Aberrane Dan Nyehangane Fabienne Nackers Emmanuel Baron Rémi Charrel Juliet Mwanga-Amumpaire |
| author_sort |
Anne-Laure Page |
| title |
Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda |
| title_short |
Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda |
| title_full |
Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda |
| title_fullStr |
Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda |
| title_full_unstemmed |
Aetiology and Outcomes of Suspected Infections of the Central Nervous System in Children in Mbarara, Uganda |
| title_sort |
aetiology and outcomes of suspected infections of the central nervous system in children in mbarara, uganda |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/abd7f92eb8454ec8b3543713f73615cc |
| work_keys_str_mv |
AT annelaurepage aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT yapboumii aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT elizabethkemigisha aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT nicolassalez aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT deborahnanjebe aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT celinelangendorf aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT saidaberrane aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT dannyehangane aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT fabiennenackers aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT emmanuelbaron aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT remicharrel aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda AT julietmwangaamumpaire aetiologyandoutcomesofsuspectedinfectionsofthecentralnervoussysteminchildreninmbararauganda |
| _version_ |
1718395061931081728 |