Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.

<h4>Objective</h4>A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, th...

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Autores principales:	Giacomo Zoppini, Anna Galletti, Giovanni Targher, Corinna Brangani, Isabella Pichiri, Carlo Negri, Vincenzo Stoico, Vittorio Cacciatori, Enzo Bonora
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f
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spelling	oai:doaj.org-article:abd8285e4c1a44a1af619f4727f4c38f2021-11-18T08:41:47ZGlycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.1932-620310.1371/journal.pone.0082733https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358222/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4>Research design and methods</h4>We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4>Results</h4>Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4>Conclusions</h4>In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.Giacomo ZoppiniAnna GallettiGiovanni TargherCorinna BranganiIsabella PichiriCarlo NegriVincenzo StoicoVittorio CacciatoriEnzo BonoraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82733 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giacomo Zoppini Anna Galletti Giovanni Targher Corinna Brangani Isabella Pichiri Carlo Negri Vincenzo Stoico Vittorio Cacciatori Enzo Bonora Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
description	<h4>Objective</h4>A correlation between glucose control and 25(OH)D metabolism has been suggested by previous studies. However, this correlation has not yet been evaluated considering the impact of chronic complications of type 2 diabetes, especially the presence of nephropathy. Thus, the aim of this study was to determine the correlation between A1C and 25(OH)D in a well characterized cohort of type 2 diabetic patients.<h4>Research design and methods</h4>We cross-sectionally examined the association between A1C and serum 25(OH) D in 715 type 2 diabetic patients attending our clinic during the years 2011-2012. The average age was 68±12 years (range 26-94 years). The relation between A1C and serum 25(OH)D levels was modelled by multiple linear regression analyses.<h4>Results</h4>Serum 25(OH)D levels were inversely associated with A1C levels (r = -0.116, p = .003). This relation maintains its independence in the multivariate analysis after adjusting for age, sex, A1C, BMI, treatment and duration of diabetes and nephropathy.<h4>Conclusions</h4>In type 2 diabetic patients, high A1C levels are associated with low concentrations of serum 25(OH)D independently of duration of diabetes, diabetic treatment and nephropathy. Future studies are needed to clarify the biological relation between glucose control and vitamin D metabolism in type 2 diabetes.
format	article
author	Giacomo Zoppini Anna Galletti Giovanni Targher Corinna Brangani Isabella Pichiri Carlo Negri Vincenzo Stoico Vittorio Cacciatori Enzo Bonora
author_facet	Giacomo Zoppini Anna Galletti Giovanni Targher Corinna Brangani Isabella Pichiri Carlo Negri Vincenzo Stoico Vittorio Cacciatori Enzo Bonora
author_sort	Giacomo Zoppini
title	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
title_short	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
title_full	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
title_fullStr	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
title_full_unstemmed	Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.
title_sort	glycated haemoglobin is inversely related to serum vitamin d levels in type 2 diabetic patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/abd8285e4c1a44a1af619f4727f4c38f
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Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients.

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