Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia

Anhedonia is considered as one of the five dimensions of negative symptoms and mainly refers to the reduction of the capacity of feeling pleasure. Increasing evidence suggests that anhedonia in schizophrenia may be partly explained by cognitive impairment. However, the associations between specific...

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Autores principales:	Lingfang Yu, Hua Ni, Zenan Wu, Xinyu Fang, Yan Chen, Dandan Wang, Chen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	schizophrenia anticipatory anhedonia consummatory anhedonia cognitive function language delayed memory Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/abd8f3248bb048b286b376a8a7a05a34
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spelling	oai:doaj.org-article:abd8f3248bb048b286b376a8a7a05a342021-12-02T08:54:36ZAssociation of Cognitive Impairment With Anhedonia in Patients With Schizophrenia1664-064010.3389/fpsyt.2021.762216https://doaj.org/article/abd8f3248bb048b286b376a8a7a05a342021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.762216/fullhttps://doaj.org/toc/1664-0640Anhedonia is considered as one of the five dimensions of negative symptoms and mainly refers to the reduction of the capacity of feeling pleasure. Increasing evidence suggests that anhedonia in schizophrenia may be partly explained by cognitive impairment. However, the associations between specific cognitive impairment and anhedonia are not fully investigated. The purpose of this study was to examine anticipatory anhedonia, consummatory anhedonia, and their cognitive associations in schizophrenia. A total number of 100 patients with schizophrenia and 67 healthy volunteers were recruited. The clinical symptoms of schizophrenia were assessed. Anticipatory pleasure, consummatory pleasure, and cognitive functions of each participant were measured. Multiple linear regression analysis was performed to investigate the influencing factors of anhedonia in schizophrenia. The results showed no significant differences in sex, age, education year, body mass index (BMI), and marital status between the schizophrenia group and healthy control group (all P > 0.05). Both anticipatory and consummatory pleasure in the schizophrenia group were significantly lower than those in the healthy control group (all P < 0.05). Immediate memory, visual spanning, language, attention, and delayed memory were significantly poorer in the schizophrenia group (all P < 0.05). The results showed that language deficit is an independent risk factor for anticipatory anhedonia (B' = 0.265, P = 0.008, 95% CI: 0.038-0.244), while delayed memory deficit is an independent risk factor for consummatory anhedonia (B' = 0.391, P < 0.001, 95% CI:0.085-0.237). To the best of our knowledge, this is the first study that reported the specific cognitive associations of anhedonia in schizophrenia. The findings have added new evidence on the influencing factors of anhedonia and provided clues for the associations between clinical manifestations of schizophrenia.Lingfang YuHua NiZenan WuXinyu FangYan ChenDandan WangChen ZhangFrontiers Media S.A.articleschizophreniaanticipatory anhedoniaconsummatory anhedoniacognitive functionlanguagedelayed memoryPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia anticipatory anhedonia consummatory anhedonia cognitive function language delayed memory Psychiatry RC435-571
spellingShingle	schizophrenia anticipatory anhedonia consummatory anhedonia cognitive function language delayed memory Psychiatry RC435-571 Lingfang Yu Hua Ni Zenan Wu Xinyu Fang Yan Chen Dandan Wang Chen Zhang Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia
description	Anhedonia is considered as one of the five dimensions of negative symptoms and mainly refers to the reduction of the capacity of feeling pleasure. Increasing evidence suggests that anhedonia in schizophrenia may be partly explained by cognitive impairment. However, the associations between specific cognitive impairment and anhedonia are not fully investigated. The purpose of this study was to examine anticipatory anhedonia, consummatory anhedonia, and their cognitive associations in schizophrenia. A total number of 100 patients with schizophrenia and 67 healthy volunteers were recruited. The clinical symptoms of schizophrenia were assessed. Anticipatory pleasure, consummatory pleasure, and cognitive functions of each participant were measured. Multiple linear regression analysis was performed to investigate the influencing factors of anhedonia in schizophrenia. The results showed no significant differences in sex, age, education year, body mass index (BMI), and marital status between the schizophrenia group and healthy control group (all P > 0.05). Both anticipatory and consummatory pleasure in the schizophrenia group were significantly lower than those in the healthy control group (all P < 0.05). Immediate memory, visual spanning, language, attention, and delayed memory were significantly poorer in the schizophrenia group (all P < 0.05). The results showed that language deficit is an independent risk factor for anticipatory anhedonia (B' = 0.265, P = 0.008, 95% CI: 0.038-0.244), while delayed memory deficit is an independent risk factor for consummatory anhedonia (B' = 0.391, P < 0.001, 95% CI:0.085-0.237). To the best of our knowledge, this is the first study that reported the specific cognitive associations of anhedonia in schizophrenia. The findings have added new evidence on the influencing factors of anhedonia and provided clues for the associations between clinical manifestations of schizophrenia.
format	article
author	Lingfang Yu Hua Ni Zenan Wu Xinyu Fang Yan Chen Dandan Wang Chen Zhang
author_facet	Lingfang Yu Hua Ni Zenan Wu Xinyu Fang Yan Chen Dandan Wang Chen Zhang
author_sort	Lingfang Yu
title	Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia
title_short	Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia
title_full	Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia
title_fullStr	Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia
title_full_unstemmed	Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia
title_sort	association of cognitive impairment with anhedonia in patients with schizophrenia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/abd8f3248bb048b286b376a8a7a05a34
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Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia

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