Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion

Background Imipenem remains active against most Gram-positive and Gram-negative organisms. This study aimed to evaluate chemical stability of imipenem in 2 commonly used concentrations when stored in 3 various temperatures. Methods Imipenem injection powder was used to prepare 5 mL and 10 mg/mL of i...

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Autores principales:	Chuleegone Sornsuvit, Purida Wientong, Suriyon Uitrakul, Siriporn Okonogi, Wasan Katip
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/abda0340b8ef4a30b66bd2df5e7cc60d
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spelling	oai:doaj.org-article:abda0340b8ef4a30b66bd2df5e7cc60d2021-12-01T23:34:29ZInfluence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion1559-325810.1177/15593258211059325https://doaj.org/article/abda0340b8ef4a30b66bd2df5e7cc60d2021-11-01T00:00:00Zhttps://doi.org/10.1177/15593258211059325https://doaj.org/toc/1559-3258Background Imipenem remains active against most Gram-positive and Gram-negative organisms. This study aimed to evaluate chemical stability of imipenem in 2 commonly used concentrations when stored in 3 various temperatures. Methods Imipenem injection powder was used to prepare 5 mL and 10 mg/mL of imipenem in .9% sodium chloride solution. Prepared solutions in PVC bags were stored at 25°C, 30°C, and 40°C. The solutions were investigated over 0, 1, 2, 3, 4, and 6 hours using HPLC analysis. The association between drug stability, temperature, and concentration was determined. Results The 5 mg/mL solutions of brand A and B imipenem mL were stable for 6 hours at 25°C, 30°C, and 40°C, respectively. For 10 mg/mL, the solution of brand A was stable for 3 hours and brand B was stable for 6 hours at 25°C. Also, brand A and B imipenem solutions at the concentration of 10 mg/mL were stable for less than 1 hour at 30°C and 40°C. Conclusion The stability of imipenem injection solution was affected by temperature and concentration. Increasing in temperature and drug concentration resulted in decreased stability of imipenem. Suitable temperature and drug concentration should be concerned when this drug is given by extended infusion.Chuleegone SornsuvitPurida WientongSuriyon UitrakulSiriporn OkonogiWasan KatipSAGE PublishingarticleTherapeutics. PharmacologyRM1-950ENDose-Response, Vol 19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Chuleegone Sornsuvit Purida Wientong Suriyon Uitrakul Siriporn Okonogi Wasan Katip Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
description	Background Imipenem remains active against most Gram-positive and Gram-negative organisms. This study aimed to evaluate chemical stability of imipenem in 2 commonly used concentrations when stored in 3 various temperatures. Methods Imipenem injection powder was used to prepare 5 mL and 10 mg/mL of imipenem in .9% sodium chloride solution. Prepared solutions in PVC bags were stored at 25°C, 30°C, and 40°C. The solutions were investigated over 0, 1, 2, 3, 4, and 6 hours using HPLC analysis. The association between drug stability, temperature, and concentration was determined. Results The 5 mg/mL solutions of brand A and B imipenem mL were stable for 6 hours at 25°C, 30°C, and 40°C, respectively. For 10 mg/mL, the solution of brand A was stable for 3 hours and brand B was stable for 6 hours at 25°C. Also, brand A and B imipenem solutions at the concentration of 10 mg/mL were stable for less than 1 hour at 30°C and 40°C. Conclusion The stability of imipenem injection solution was affected by temperature and concentration. Increasing in temperature and drug concentration resulted in decreased stability of imipenem. Suitable temperature and drug concentration should be concerned when this drug is given by extended infusion.
format	article
author	Chuleegone Sornsuvit Purida Wientong Suriyon Uitrakul Siriporn Okonogi Wasan Katip
author_facet	Chuleegone Sornsuvit Purida Wientong Suriyon Uitrakul Siriporn Okonogi Wasan Katip
author_sort	Chuleegone Sornsuvit
title	Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
title_short	Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
title_full	Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
title_fullStr	Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
title_full_unstemmed	Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion
title_sort	influence of concentration and temperature on stability of imipenem focused on solutions for extended infusion
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/abda0340b8ef4a30b66bd2df5e7cc60d
work_keys_str_mv	AT chuleegonesornsuvit influenceofconcentrationandtemperatureonstabilityofimipenemfocusedonsolutionsforextendedinfusion AT puridawientong influenceofconcentrationandtemperatureonstabilityofimipenemfocusedonsolutionsforextendedinfusion AT suriyonuitrakul influenceofconcentrationandtemperatureonstabilityofimipenemfocusedonsolutionsforextendedinfusion AT siripornokonogi influenceofconcentrationandtemperatureonstabilityofimipenemfocusedonsolutionsforextendedinfusion AT wasankatip influenceofconcentrationandtemperatureonstabilityofimipenemfocusedonsolutionsforextendedinfusion
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Influence of Concentration and Temperature on Stability of Imipenem Focused on Solutions for Extended Infusion

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