New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in <italic toggle="yes">Bordetella</italic> Virulence

New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in <italic toggle="yes">Bordetella</italic> Virulence

ABSTRACT Bordetella filamentous hemagglutinin (FHA), a primary component of acellular pertussis vaccines, contributes to virulence, but how it functions mechanistically is unclear. FHA is first synthesized as an ~370-kDa preproprotein called FhaB. Removal of an N-terminal signal peptide and a large...

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Autores principales: Jeffrey A. Melvin, Erich V. Scheller, Christopher R. Noël, Peggy A. Cotter
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/abdb820fc385442cb40926f0005786cc
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