Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Cardiomyocytes obtained from human induced pluripotent stem cells are increasingly used for drug testing, but they are not always predictive of the heart contractile responses. Here the authors develop a method to measure cytosolic calcium, action potentials and contraction simultaneously, to achiev...

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Autores principales:	Berend J. van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G. J. Tertoolen, Christine L. Mummery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abddfcae49e247a2a2aae22c0b35fcce
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spelling	oai:doaj.org-article:abddfcae49e247a2a2aae22c0b35fcce2021-12-02T15:35:30ZSimultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes10.1038/s41467-019-12354-82041-1723https://doaj.org/article/abddfcae49e247a2a2aae22c0b35fcce2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12354-8https://doaj.org/toc/2041-1723Cardiomyocytes obtained from human induced pluripotent stem cells are increasingly used for drug testing, but they are not always predictive of the heart contractile responses. Here the authors develop a method to measure cytosolic calcium, action potentials and contraction simultaneously, to achieve higher sensitivity for drug screenings.Berend J. van MeerAna KrotenbergLuca SalaRichard P. DavisThomas EschenhagenChris DenningLeon G. J. TertoolenChristine L. MummeryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Berend J. van Meer Ana Krotenberg Luca Sala Richard P. Davis Thomas Eschenhagen Chris Denning Leon G. J. Tertoolen Christine L. Mummery Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
description	Cardiomyocytes obtained from human induced pluripotent stem cells are increasingly used for drug testing, but they are not always predictive of the heart contractile responses. Here the authors develop a method to measure cytosolic calcium, action potentials and contraction simultaneously, to achieve higher sensitivity for drug screenings.
format	article
author	Berend J. van Meer Ana Krotenberg Luca Sala Richard P. Davis Thomas Eschenhagen Chris Denning Leon G. J. Tertoolen Christine L. Mummery
author_facet	Berend J. van Meer Ana Krotenberg Luca Sala Richard P. Davis Thomas Eschenhagen Chris Denning Leon G. J. Tertoolen Christine L. Mummery
author_sort	Berend J. van Meer
title	Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
title_short	Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
title_full	Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
title_fullStr	Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
title_full_unstemmed	Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
title_sort	simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hipsc-derived cardiomyocytes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/abddfcae49e247a2a2aae22c0b35fcce
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Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

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