Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes

Cardiomyocytes obtained from human induced pluripotent stem cells are increasingly used for drug testing, but they are not always predictive of the heart contractile responses. Here the authors develop a method to measure cytosolic calcium, action potentials and contraction simultaneously, to achiev...

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Autores principales: Berend J. van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G. J. Tertoolen, Christine L. Mummery
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/abddfcae49e247a2a2aae22c0b35fcce
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