Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

Pyruvate kinase M2 (PKM2) activity is regulated by the availability of metabolic intermediates for nucleotide and amino acid synthesis. Here, the authors show that PKM2 citrullination by PADI1 and PADI3 lowers its sensitivity to metabolic inhibitors leading to increased glycolysis and reduced cancer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sébastien Coassolo, Guillaume Davidson, Luc Negroni, Giovanni Gambi, Sylvain Daujat, Christophe Romier, Irwin Davidson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abe0909d891949838e266bade71dfb62
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:abe0909d891949838e266bade71dfb62
record_format	dspace
spelling	oai:doaj.org-article:abe0909d891949838e266bade71dfb622021-12-02T16:30:42ZCitrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation10.1038/s41467-021-21960-42041-1723https://doaj.org/article/abe0909d891949838e266bade71dfb622021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21960-4https://doaj.org/toc/2041-1723Pyruvate kinase M2 (PKM2) activity is regulated by the availability of metabolic intermediates for nucleotide and amino acid synthesis. Here, the authors show that PKM2 citrullination by PADI1 and PADI3 lowers its sensitivity to metabolic inhibitors leading to increased glycolysis and reduced cancer cell proliferation.Sébastien CoassoloGuillaume DavidsonLuc NegroniGiovanni GambiSylvain DaujatChristophe RomierIrwin DavidsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sébastien Coassolo Guillaume Davidson Luc Negroni Giovanni Gambi Sylvain Daujat Christophe Romier Irwin Davidson Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
description	Pyruvate kinase M2 (PKM2) activity is regulated by the availability of metabolic intermediates for nucleotide and amino acid synthesis. Here, the authors show that PKM2 citrullination by PADI1 and PADI3 lowers its sensitivity to metabolic inhibitors leading to increased glycolysis and reduced cancer cell proliferation.
format	article
author	Sébastien Coassolo Guillaume Davidson Luc Negroni Giovanni Gambi Sylvain Daujat Christophe Romier Irwin Davidson
author_facet	Sébastien Coassolo Guillaume Davidson Luc Negroni Giovanni Gambi Sylvain Daujat Christophe Romier Irwin Davidson
author_sort	Sébastien Coassolo
title	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
title_short	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
title_full	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
title_fullStr	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
title_full_unstemmed	Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation
title_sort	citrullination of pyruvate kinase m2 by padi1 and padi3 regulates glycolysis and cancer cell proliferation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abe0909d891949838e266bade71dfb62
work_keys_str_mv	AT sebastiencoassolo citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation AT guillaumedavidson citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation AT lucnegroni citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation AT giovannigambi citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation AT sylvaindaujat citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation AT christopheromier citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation AT irwindavidson citrullinationofpyruvatekinasem2bypadi1andpadi3regulatesglycolysisandcancercellproliferation
_version_	1718383949646921728

Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation

Ejemplares similares