Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source

ABSTRACT Acrolein is a highly reactive electrophile causing toxic effects, such as DNA and protein adduction, oxidative stress, endoplasmic reticulum stress, immune dysfunction, and membrane damage. This Opinion/Hypothesis provides an overview of endogenous and exogenous acrolein sources, acrolein’s...

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Autores principales:	Jianbo Zhang, Shana Sturla, Christophe Lacroix, Clarissa Schwab
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	endogenous acrolein glycerol metabolism gut microbiota reuterin toxicity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/abe19fa80a92433aaacf237a1fdf66ed
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spelling	oai:doaj.org-article:abe19fa80a92433aaacf237a1fdf66ed2021-11-15T15:53:25ZGut Microbial Glycerol Metabolism as an Endogenous Acrolein Source10.1128/mBio.01947-172150-7511https://doaj.org/article/abe19fa80a92433aaacf237a1fdf66ed2018-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01947-17https://doaj.org/toc/2150-7511ABSTRACT Acrolein is a highly reactive electrophile causing toxic effects, such as DNA and protein adduction, oxidative stress, endoplasmic reticulum stress, immune dysfunction, and membrane damage. This Opinion/Hypothesis provides an overview of endogenous and exogenous acrolein sources, acrolein’s mode of action, and its metabolic fate. Recent reports underpin the finding that gut microbial glycerol metabolism leading to the formation of reuterin is an additional source of endogenous acrolein. Reuterin is an antimicrobial multicomponent system consisting of 3-hydroxypropionaldehyde, its dimer and hydrate, and also acrolein. The major conclusion is that gut microbes can metabolize glycerol to reuterin and that this transformation occurs in vivo. Given the known toxicity of acrolein, the observation that acrolein is formed in the gut necessitates further investigations on functional relevance for gut microbiota and the host.Jianbo ZhangShana SturlaChristophe LacroixClarissa SchwabAmerican Society for Microbiologyarticleendogenous acroleinglycerol metabolismgut microbiotareuterintoxicityMicrobiologyQR1-502ENmBio, Vol 9, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	endogenous acrolein glycerol metabolism gut microbiota reuterin toxicity Microbiology QR1-502
spellingShingle	endogenous acrolein glycerol metabolism gut microbiota reuterin toxicity Microbiology QR1-502 Jianbo Zhang Shana Sturla Christophe Lacroix Clarissa Schwab Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
description	ABSTRACT Acrolein is a highly reactive electrophile causing toxic effects, such as DNA and protein adduction, oxidative stress, endoplasmic reticulum stress, immune dysfunction, and membrane damage. This Opinion/Hypothesis provides an overview of endogenous and exogenous acrolein sources, acrolein’s mode of action, and its metabolic fate. Recent reports underpin the finding that gut microbial glycerol metabolism leading to the formation of reuterin is an additional source of endogenous acrolein. Reuterin is an antimicrobial multicomponent system consisting of 3-hydroxypropionaldehyde, its dimer and hydrate, and also acrolein. The major conclusion is that gut microbes can metabolize glycerol to reuterin and that this transformation occurs in vivo. Given the known toxicity of acrolein, the observation that acrolein is formed in the gut necessitates further investigations on functional relevance for gut microbiota and the host.
format	article
author	Jianbo Zhang Shana Sturla Christophe Lacroix Clarissa Schwab
author_facet	Jianbo Zhang Shana Sturla Christophe Lacroix Clarissa Schwab
author_sort	Jianbo Zhang
title	Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
title_short	Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
title_full	Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
title_fullStr	Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
title_full_unstemmed	Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source
title_sort	gut microbial glycerol metabolism as an endogenous acrolein source
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/abe19fa80a92433aaacf237a1fdf66ed
work_keys_str_mv	AT jianbozhang gutmicrobialglycerolmetabolismasanendogenousacroleinsource AT shanasturla gutmicrobialglycerolmetabolismasanendogenousacroleinsource AT christophelacroix gutmicrobialglycerolmetabolismasanendogenousacroleinsource AT clarissaschwab gutmicrobialglycerolmetabolismasanendogenousacroleinsource
_version_	1718427295072387072

Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source

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