Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders

Abstract This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136) is less flexible than that of healthy individuals (N = 53) in the context of phys...

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Autores principales:	Ryan Smith, Justin S. Feinstein, Rayus Kuplicki, Katherine L. Forthman, Jennifer L. Stewart, Martin P. Paulus, Tulsa 1000 Investigators, Sahib S. Khalsa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abe34f3d81b84ca19cd6ecfe6a8766ce
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spelling	oai:doaj.org-article:abe34f3d81b84ca19cd6ecfe6a8766ce2021-12-02T15:23:47ZPerceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders10.1038/s41598-021-81307-32045-2322https://doaj.org/article/abe34f3d81b84ca19cd6ecfe6a8766ce2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81307-3https://doaj.org/toc/2045-2322Abstract This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136) is less flexible than that of healthy individuals (N = 53) in the context of physiological perturbation. Cardiac interoception was assessed via heartbeat tapping when: (1) guessing was allowed; (2) guessing was not allowed; and (3) experiencing an interoceptive perturbation (inspiratory breath hold) expected to amplify cardiac sensation. Healthy participants showed performance improvements across the three conditions, whereas those with depression/anxiety and/or substance use disorder showed minimal improvement. Machine learning analyses suggested that individual differences in these improvements were negatively related to anxiety sensitivity, but explained relatively little variance in performance. These results reveal a perceptual insensitivity to the modulation of interoceptive signals that was evident across several common psychiatric disorders, suggesting that interoceptive deficits in the realm of psychopathology manifest most prominently during states of homeostatic perturbation.Ryan SmithJustin S. FeinsteinRayus KuplickiKatherine L. ForthmanJennifer L. StewartMartin P. PaulusTulsa 1000 InvestigatorsSahib S. KhalsaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryan Smith Justin S. Feinstein Rayus Kuplicki Katherine L. Forthman Jennifer L. Stewart Martin P. Paulus Tulsa 1000 Investigators Sahib S. Khalsa Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
description	Abstract This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136) is less flexible than that of healthy individuals (N = 53) in the context of physiological perturbation. Cardiac interoception was assessed via heartbeat tapping when: (1) guessing was allowed; (2) guessing was not allowed; and (3) experiencing an interoceptive perturbation (inspiratory breath hold) expected to amplify cardiac sensation. Healthy participants showed performance improvements across the three conditions, whereas those with depression/anxiety and/or substance use disorder showed minimal improvement. Machine learning analyses suggested that individual differences in these improvements were negatively related to anxiety sensitivity, but explained relatively little variance in performance. These results reveal a perceptual insensitivity to the modulation of interoceptive signals that was evident across several common psychiatric disorders, suggesting that interoceptive deficits in the realm of psychopathology manifest most prominently during states of homeostatic perturbation.
format	article
author	Ryan Smith Justin S. Feinstein Rayus Kuplicki Katherine L. Forthman Jennifer L. Stewart Martin P. Paulus Tulsa 1000 Investigators Sahib S. Khalsa
author_facet	Ryan Smith Justin S. Feinstein Rayus Kuplicki Katherine L. Forthman Jennifer L. Stewart Martin P. Paulus Tulsa 1000 Investigators Sahib S. Khalsa
author_sort	Ryan Smith
title	Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
title_short	Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
title_full	Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
title_fullStr	Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
title_full_unstemmed	Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
title_sort	perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abe34f3d81b84ca19cd6ecfe6a8766ce
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Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders

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