First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera

Abstract In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the...

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Autores principales:	Aya Kishimoto, Jun Kataoka, Takanori Taya, Leo Tagawa, Saku Mochizuki, Shinji Ohsuka, Yuto Nagao, Keisuke Kurita, Mitsutaka Yamaguchi, Naoki Kawachi, Keiko Matsunaga, Hayato Ikeda, Eku Shimosegawa, Jun Hatazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abe3650360a6494091ea74f3ad524647
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spelling	oai:doaj.org-article:abe3650360a6494091ea74f3ad5246472021-12-02T12:32:31ZFirst demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera10.1038/s41598-017-02377-w2045-2322https://doaj.org/article/abe3650360a6494091ea74f3ad5246472017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02377-whttps://doaj.org/toc/2045-2322Abstract In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.Aya KishimotoJun KataokaTakanori TayaLeo TagawaSaku MochizukiShinji OhsukaYuto NagaoKeisuke KuritaMitsutaka YamaguchiNaoki KawachiKeiko MatsunagaHayato IkedaEku ShimosegawaJun HatazawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aya Kishimoto Jun Kataoka Takanori Taya Leo Tagawa Saku Mochizuki Shinji Ohsuka Yuto Nagao Keisuke Kurita Mitsutaka Yamaguchi Naoki Kawachi Keiko Matsunaga Hayato Ikeda Eku Shimosegawa Jun Hatazawa First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
description	Abstract In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities. In this paper, we developed an ultra-compact Compton camera that weighs only 580 g. The camera consists of fine-pixelized Ce-doped Gd3Al2Ga3O12 scintillators coupled with multi-pixel photon counter arrays. We first investigated the 3-D imaging capability of our camera system for a diffuse source of a planar geometry, and then conducted small animal imaging as pre-clinical evaluation. For the first time, we successfully carried out the 3-D color imaging of a live mouse in just 2 h. By using tri-color gamma-ray fusion images, we confirmed that 131I, 85Sr, and 65Zn can be new tracers that concentrate in each target organ.
format	article
author	Aya Kishimoto Jun Kataoka Takanori Taya Leo Tagawa Saku Mochizuki Shinji Ohsuka Yuto Nagao Keisuke Kurita Mitsutaka Yamaguchi Naoki Kawachi Keiko Matsunaga Hayato Ikeda Eku Shimosegawa Jun Hatazawa
author_facet	Aya Kishimoto Jun Kataoka Takanori Taya Leo Tagawa Saku Mochizuki Shinji Ohsuka Yuto Nagao Keisuke Kurita Mitsutaka Yamaguchi Naoki Kawachi Keiko Matsunaga Hayato Ikeda Eku Shimosegawa Jun Hatazawa
author_sort	Aya Kishimoto
title	First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
title_short	First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
title_full	First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
title_fullStr	First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
title_full_unstemmed	First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera
title_sort	first demonstration of multi-color 3-d in vivo imaging using ultra-compact compton camera
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/abe3650360a6494091ea74f3ad524647
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First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera

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