How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA

The cyanophage S-2L incorporates 2-aminoadenine (Z) instead of adenine (A) in its genome. Here, the authors provide an explanation for the absence of A in S-2L genome by identifying and characterising functionally and structurally both the HD phosphohydrolase (datZ) that specifically cleaves dATP, a...

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Autores principales:	Dariusz Czernecki, Pierre Legrand, Mustafa Tekpinar, Sandrine Rosario, Pierre-Alexandre Kaminski, Marc Delarue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abe6a0fc434445db8149e9dae08610a3
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spelling	oai:doaj.org-article:abe6a0fc434445db8149e9dae08610a32021-12-02T18:28:38ZHow cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA10.1038/s41467-021-22626-x2041-1723https://doaj.org/article/abe6a0fc434445db8149e9dae08610a32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22626-xhttps://doaj.org/toc/2041-1723The cyanophage S-2L incorporates 2-aminoadenine (Z) instead of adenine (A) in its genome. Here, the authors provide an explanation for the absence of A in S-2L genome by identifying and characterising functionally and structurally both the HD phosphohydrolase (datZ) that specifically cleaves dATP, and the sole DNA primase-polymerase of S-2L, nonspecific of dATP or dZTP.Dariusz CzerneckiPierre LegrandMustafa TekpinarSandrine RosarioPierre-Alexandre KaminskiMarc DelarueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dariusz Czernecki Pierre Legrand Mustafa Tekpinar Sandrine Rosario Pierre-Alexandre Kaminski Marc Delarue How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
description	The cyanophage S-2L incorporates 2-aminoadenine (Z) instead of adenine (A) in its genome. Here, the authors provide an explanation for the absence of A in S-2L genome by identifying and characterising functionally and structurally both the HD phosphohydrolase (datZ) that specifically cleaves dATP, and the sole DNA primase-polymerase of S-2L, nonspecific of dATP or dZTP.
format	article
author	Dariusz Czernecki Pierre Legrand Mustafa Tekpinar Sandrine Rosario Pierre-Alexandre Kaminski Marc Delarue
author_facet	Dariusz Czernecki Pierre Legrand Mustafa Tekpinar Sandrine Rosario Pierre-Alexandre Kaminski Marc Delarue
author_sort	Dariusz Czernecki
title	How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
title_short	How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
title_full	How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
title_fullStr	How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
title_full_unstemmed	How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA
title_sort	how cyanophage s-2l rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its dna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abe6a0fc434445db8149e9dae08610a3
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How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA

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