Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical setting. Its pathogenesis was associated with metabolic disorder, especially defective fatty acids oxidation (FAO). However, whether promoting FAO could prevent AF occurrence and development remains elusive. In this...

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Autores principales:	Yudi Zhang, Yuping Fu, Tiannan Jiang, Binghua Liu, Hongke Sun, Ying Zhang, Boyuan Fan, Xiaoli Li, Xinghua Qin, Qiangsun Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	atrial fibrillation obesity fatty acids oxidation lipotoxicity l-carnitine AMPK (5′-AMP activated kinase) Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/abe7ed0a1ed043b0b9513ee0d2ab6881
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Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity

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