Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity

Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical setting. Its pathogenesis was associated with metabolic disorder, especially defective fatty acids oxidation (FAO). However, whether promoting FAO could prevent AF occurrence and development remains elusive. In this...

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Bibliographic Details
Main Authors: Yudi Zhang, Yuping Fu, Tiannan Jiang, Binghua Liu, Hongke Sun, Ying Zhang, Boyuan Fan, Xiaoli Li, Xinghua Qin, Qiangsun Zheng
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
atrial fibrillation
obesity
fatty acids oxidation
lipotoxicity
l-carnitine
AMPK (5′-AMP activated kinase)
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/abe7ed0a1ed043b0b9513ee0d2ab6881
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