Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent

Several extracts of Syzygium species have been shown to inhibit the growth of some fungal microorganisms implicated in skin diseases, such as Candida albicans included S. samarangense. However, an antifungal test of C. Albicans on this plant's stem bark had not been reported. This study aimed t...

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Autores principales:	Tukiran Tukiran, Suyatno Suyatno, Frisca Nadya Safitri
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	antifungal c. albicans flavonoids lc-esi-ms s. samarangense Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/abecae9fab2e4cc69cfe8d9c30bb3549
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spelling	oai:doaj.org-article:abecae9fab2e4cc69cfe8d9c30bb35492021-12-02T14:01:33ZIdentification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent1411-94202460-157810.22146/ijc.55366https://doaj.org/article/abecae9fab2e4cc69cfe8d9c30bb35492021-03-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/55366https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578Several extracts of Syzygium species have been shown to inhibit the growth of some fungal microorganisms implicated in skin diseases, such as Candida albicans included S. samarangense. However, an antifungal test of C. Albicans on this plant's stem bark had not been reported. This study aimed to identify chemical constituents of the selected fraction from dichloromethane extracts of the stem bark of S. samarangense and determine the antifungal activity of the selected fraction at various concentrations on C. Albicans. The identification of the chemical constituent of the selected fraction has been performed by the LC-ESI-MS technique. An antifungal test of the selected fraction was carried out using the disk diffusion method. The samples used included the selected fraction with 5 variations of concentration (2.5; 2.0; 1.5; 1.0; and 0.5%), positive control (ketoconazole 1%), and negative control (DMSO). The results showed that the selected fraction has antifungal activity on C. Albicans. The results showed that the selected fraction contains four flavonoids: pinocembrin, uvangoletin, stercurensin, and aurentiacin. Due to antifungal activity on C. Albicans, it has moderate activity at a concentration of 2.5%, while concentrations of 2.0, 1.5, 1.0, and 0.5% have weak activity.Tukiran TukiranSuyatno SuyatnoFrisca Nadya SafitriDepartment of Chemistry, Universitas Gadjah Madaarticleantifungalc. albicansflavonoidslc-esi-mss. samarangenseChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 2, Pp 340-349 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antifungal c. albicans flavonoids lc-esi-ms s. samarangense Chemistry QD1-999
spellingShingle	antifungal c. albicans flavonoids lc-esi-ms s. samarangense Chemistry QD1-999 Tukiran Tukiran Suyatno Suyatno Frisca Nadya Safitri Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent
description	Several extracts of Syzygium species have been shown to inhibit the growth of some fungal microorganisms implicated in skin diseases, such as Candida albicans included S. samarangense. However, an antifungal test of C. Albicans on this plant's stem bark had not been reported. This study aimed to identify chemical constituents of the selected fraction from dichloromethane extracts of the stem bark of S. samarangense and determine the antifungal activity of the selected fraction at various concentrations on C. Albicans. The identification of the chemical constituent of the selected fraction has been performed by the LC-ESI-MS technique. An antifungal test of the selected fraction was carried out using the disk diffusion method. The samples used included the selected fraction with 5 variations of concentration (2.5; 2.0; 1.5; 1.0; and 0.5%), positive control (ketoconazole 1%), and negative control (DMSO). The results showed that the selected fraction has antifungal activity on C. Albicans. The results showed that the selected fraction contains four flavonoids: pinocembrin, uvangoletin, stercurensin, and aurentiacin. Due to antifungal activity on C. Albicans, it has moderate activity at a concentration of 2.5%, while concentrations of 2.0, 1.5, 1.0, and 0.5% have weak activity.
format	article
author	Tukiran Tukiran Suyatno Suyatno Frisca Nadya Safitri
author_facet	Tukiran Tukiran Suyatno Suyatno Frisca Nadya Safitri
author_sort	Tukiran Tukiran
title	Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent
title_short	Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent
title_full	Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent
title_fullStr	Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent
title_full_unstemmed	Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent
title_sort	identification of the chemical constituents of the selected fraction of the dichloromethane extract of <i>syzygium samarangense</i> stem bark using lc-esi-ms and evaluation its potential as antifungal agent
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/abecae9fab2e4cc69cfe8d9c30bb3549
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_version_	1718392161195524096

Identification of the Chemical Constituents of the Selected Fraction of the Dichloromethane Extract of <i>Syzygium samarangense</i> Stem Bark Using LC-ESI-MS and Evaluation Its Potential as Antifungal Agent

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