Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal

Several studies using neuroimaging techniques have established a positive relationship between physical activity (PA) and brain structure and function in older populations. However, the use of subjective measures of PA and the lack of multimodal neuroimaging approaches have limited the understanding...

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Autores principales:	Célia Domingos, Maria Picó-Pérez, Ricardo Magalhães, Mariana Moreira, Nuno Sousa, José Miguel Pêgo, Nadine Correia Santos
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	physical activity elderly brain health neuroimaging accelerometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/abee4440604348abb5c2b8d4fd52e96b
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spelling	oai:doaj.org-article:abee4440604348abb5c2b8d4fd52e96b2021-12-01T19:23:22ZFree-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal1663-436510.3389/fnagi.2021.729060https://doaj.org/article/abee4440604348abb5c2b8d4fd52e96b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.729060/fullhttps://doaj.org/toc/1663-4365Several studies using neuroimaging techniques have established a positive relationship between physical activity (PA) and brain structure and function in older populations. However, the use of subjective measures of PA and the lack of multimodal neuroimaging approaches have limited the understanding of this association. This study aims to explore the associations between PA and brain structure and function by objectively evaluating PA. Community-dwelling cognitively healthy older adults (without diagnosed cognitive, neurological or degenerative disease) were recruited from local health centers and local gyms. In a cross-sectional design, participants were evaluated regarding cognitive, clinical, anthropometric, physical performance, and lifestyle characteristics. A 3 T magnetic resonance imaging (MRI) was performed for structural and functional brain measures. PA time and level was assessed via a Xiaomi Mi Band 2® worn for 15 consecutive days. Participants (n = 110, after inclusion/exclusion criteria and completion of all evaluations) were 58 females (56%), with an average age of 68.42 years old (SD = 3.12), most were active. Multiple regression analysis revealed that higher time spent in vigorous PA associated with larger left parahippocampal gyrus and right hippocampus volumes. Furthermore, the analysis of the functional connectome indicated a greater functional connectivity (FC) between the frontal gyrus, cingulate gyrus, occipital inferior lobe for light, moderate, and total PA time, and sedentary time associated with lower FC in the same networks. Overall, the structural and functional findings may provide evidence on the relevant association between PA and brain health in aging.Célia DomingosCélia DomingosCélia DomingosCélia DomingosMaria Picó-PérezMaria Picó-PérezMaria Picó-PérezRicardo MagalhãesMariana MoreiraNuno SousaNuno SousaNuno SousaJosé Miguel PêgoJosé Miguel PêgoJosé Miguel PêgoJosé Miguel PêgoNadine Correia SantosNadine Correia SantosNadine Correia SantosNadine Correia SantosFrontiers Media S.A.articlephysical activityelderlybrain healthneuroimagingaccelerometryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	physical activity elderly brain health neuroimaging accelerometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	physical activity elderly brain health neuroimaging accelerometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Célia Domingos Célia Domingos Célia Domingos Célia Domingos Maria Picó-Pérez Maria Picó-Pérez Maria Picó-Pérez Ricardo Magalhães Mariana Moreira Nuno Sousa Nuno Sousa Nuno Sousa José Miguel Pêgo José Miguel Pêgo José Miguel Pêgo José Miguel Pêgo Nadine Correia Santos Nadine Correia Santos Nadine Correia Santos Nadine Correia Santos Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal
description	Several studies using neuroimaging techniques have established a positive relationship between physical activity (PA) and brain structure and function in older populations. However, the use of subjective measures of PA and the lack of multimodal neuroimaging approaches have limited the understanding of this association. This study aims to explore the associations between PA and brain structure and function by objectively evaluating PA. Community-dwelling cognitively healthy older adults (without diagnosed cognitive, neurological or degenerative disease) were recruited from local health centers and local gyms. In a cross-sectional design, participants were evaluated regarding cognitive, clinical, anthropometric, physical performance, and lifestyle characteristics. A 3 T magnetic resonance imaging (MRI) was performed for structural and functional brain measures. PA time and level was assessed via a Xiaomi Mi Band 2® worn for 15 consecutive days. Participants (n = 110, after inclusion/exclusion criteria and completion of all evaluations) were 58 females (56%), with an average age of 68.42 years old (SD = 3.12), most were active. Multiple regression analysis revealed that higher time spent in vigorous PA associated with larger left parahippocampal gyrus and right hippocampus volumes. Furthermore, the analysis of the functional connectome indicated a greater functional connectivity (FC) between the frontal gyrus, cingulate gyrus, occipital inferior lobe for light, moderate, and total PA time, and sedentary time associated with lower FC in the same networks. Overall, the structural and functional findings may provide evidence on the relevant association between PA and brain health in aging.
format	article
author	Célia Domingos Célia Domingos Célia Domingos Célia Domingos Maria Picó-Pérez Maria Picó-Pérez Maria Picó-Pérez Ricardo Magalhães Mariana Moreira Nuno Sousa Nuno Sousa Nuno Sousa José Miguel Pêgo José Miguel Pêgo José Miguel Pêgo José Miguel Pêgo Nadine Correia Santos Nadine Correia Santos Nadine Correia Santos Nadine Correia Santos
author_facet	Célia Domingos Célia Domingos Célia Domingos Célia Domingos Maria Picó-Pérez Maria Picó-Pérez Maria Picó-Pérez Ricardo Magalhães Mariana Moreira Nuno Sousa Nuno Sousa Nuno Sousa José Miguel Pêgo José Miguel Pêgo José Miguel Pêgo José Miguel Pêgo Nadine Correia Santos Nadine Correia Santos Nadine Correia Santos Nadine Correia Santos
author_sort	Célia Domingos
title	Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal
title_short	Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal
title_full	Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal
title_fullStr	Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal
title_full_unstemmed	Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal
title_sort	free-living physical activity measured with a wearable device is associated with larger hippocampus volume and greater functional connectivity in healthy older adults: an observational, cross-sectional study in northern portugal
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/abee4440604348abb5c2b8d4fd52e96b
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Free-Living Physical Activity Measured With a Wearable Device Is Associated With Larger Hippocampus Volume and Greater Functional Connectivity in Healthy Older Adults: An Observational, Cross-Sectional Study in Northern Portugal

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