Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS

Abstract. Samiyarsih S, Fitrianto N, Proklamasiningsih E, Juwarno, Muljowati JS. 2020. Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS. Biodiversitas 21: 1332-1344. Catharanthus roseus (L.) G is an important medicinal p...

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Autores principales:	siti samiyarsih, NUR FITRIANTO, ELLY PROKLAMASININGSIH, JUWARNO, JUNI SAFITRI MULJOWATI
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2020
Materias:	antimicrobial, catharanthus roseus, gc-ms, phytochemical Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/abef8696013b41338711541f5ea4ea1b
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spelling	oai:doaj.org-article:abef8696013b41338711541f5ea4ea1b2021-11-22T00:34:40ZPhytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS1412-033X2085-472210.13057/biodiv/d210409https://doaj.org/article/abef8696013b41338711541f5ea4ea1b2020-03-01T00:00:00Zhttps://smujo.id/biodiv/article/view/4937https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Samiyarsih S, Fitrianto N, Proklamasiningsih E, Juwarno, Muljowati JS. 2020. Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS. Biodiversitas 21: 1332-1344. Catharanthus roseus (L.) G is an important medicinal plant to evaluate the possibility of novel pharmaceuticals since most of the bacterial pathogens are developing resistance against antibiotics. This research aimed to determine the phytochemical diversity of methanol extract of eight cultivars of C. roseus and to evaluate for possible antimicrobial (antifungal and antibacterial) activities. It is the first research to compare phytochemicals and antimicrobial potential among C. roseus cultivars. The compound obtained was screened by Gas Chromatography-Mass Spectrometry (GC-MS) method. While agar-well disc diffusion method was employed to measure antimicrobial activity against Escherichia coli, Staphylococcus aureus, Aspergillus flavus and Aspergillus niger. Based on GC-MS analysis, a total of 18 significantly different metabolite compounds. The abundances of phytochemical compounds (18 classes total) in each cultivar were Dark Pink (66%), Pink (50%), Purple Pink (44%), Pale Pink (27%), White (44%), Milky White (50%), Whitish pink (50%) and Pinkish Red (55%). The leaves extracts showed antimicrobial activity with inhibition zones ranging from 6.40-22.00 mm and 3.35-8.20 mm, respectively. The best antimicrobial activity against E. coli, S. aureus, A. flavus, and A. niger with the zone of inhibition 16.10±1.67 mm, 22.00±0.33 mm, 6.05±0.67 mm and 8.20±0.50 mm respectively by Dark Pink cultivar.siti samiyarsihNUR FITRIANTOELLY PROKLAMASININGSIHJUWARNOJUNI SAFITRI MULJOWATIMBI & UNS Soloarticleantimicrobial, catharanthus roseus, gc-ms, phytochemicalBiology (General)QH301-705.5ENBiodiversitas, Vol 21, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial, catharanthus roseus, gc-ms, phytochemical Biology (General) QH301-705.5
spellingShingle	antimicrobial, catharanthus roseus, gc-ms, phytochemical Biology (General) QH301-705.5 siti samiyarsih NUR FITRIANTO ELLY PROKLAMASININGSIH JUWARNO JUNI SAFITRI MULJOWATI Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS
description	Abstract. Samiyarsih S, Fitrianto N, Proklamasiningsih E, Juwarno, Muljowati JS. 2020. Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS. Biodiversitas 21: 1332-1344. Catharanthus roseus (L.) G is an important medicinal plant to evaluate the possibility of novel pharmaceuticals since most of the bacterial pathogens are developing resistance against antibiotics. This research aimed to determine the phytochemical diversity of methanol extract of eight cultivars of C. roseus and to evaluate for possible antimicrobial (antifungal and antibacterial) activities. It is the first research to compare phytochemicals and antimicrobial potential among C. roseus cultivars. The compound obtained was screened by Gas Chromatography-Mass Spectrometry (GC-MS) method. While agar-well disc diffusion method was employed to measure antimicrobial activity against Escherichia coli, Staphylococcus aureus, Aspergillus flavus and Aspergillus niger. Based on GC-MS analysis, a total of 18 significantly different metabolite compounds. The abundances of phytochemical compounds (18 classes total) in each cultivar were Dark Pink (66%), Pink (50%), Purple Pink (44%), Pale Pink (27%), White (44%), Milky White (50%), Whitish pink (50%) and Pinkish Red (55%). The leaves extracts showed antimicrobial activity with inhibition zones ranging from 6.40-22.00 mm and 3.35-8.20 mm, respectively. The best antimicrobial activity against E. coli, S. aureus, A. flavus, and A. niger with the zone of inhibition 16.10±1.67 mm, 22.00±0.33 mm, 6.05±0.67 mm and 8.20±0.50 mm respectively by Dark Pink cultivar.
format	article
author	siti samiyarsih NUR FITRIANTO ELLY PROKLAMASININGSIH JUWARNO JUNI SAFITRI MULJOWATI
author_facet	siti samiyarsih NUR FITRIANTO ELLY PROKLAMASININGSIH JUWARNO JUNI SAFITRI MULJOWATI
author_sort	siti samiyarsih
title	Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS
title_short	Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS
title_full	Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS
title_fullStr	Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS
title_full_unstemmed	Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS
title_sort	phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of catharanthus roseus using gc-ms
publisher	MBI & UNS Solo
publishDate	2020
url	https://doaj.org/article/abef8696013b41338711541f5ea4ea1b
work_keys_str_mv	AT sitisamiyarsih phytochemicaldiversityandantimicrobialpropertiesofmethanolextractofseveralcultivarsofcatharanthusroseususinggcms AT nurfitrianto phytochemicaldiversityandantimicrobialpropertiesofmethanolextractofseveralcultivarsofcatharanthusroseususinggcms AT ellyproklamasiningsih phytochemicaldiversityandantimicrobialpropertiesofmethanolextractofseveralcultivarsofcatharanthusroseususinggcms AT juwarno phytochemicaldiversityandantimicrobialpropertiesofmethanolextractofseveralcultivarsofcatharanthusroseususinggcms AT junisafitrimuljowati phytochemicaldiversityandantimicrobialpropertiesofmethanolextractofseveralcultivarsofcatharanthusroseususinggcms
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Phytochemical diversity and antimicrobial properties of methanol extract of several cultivars of Catharanthus roseus using GC-MS

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