Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.

The bacterium Escherichia coli in suspension in a liquid medium swims by a succession of runs and tumbles, effectively describing a random walk. The tumbles randomize incompletely, i.e. with a directional persistence, the orientation taken by the bacterium. Here, we model these tumbles by an active...

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Autores principales:	Jonathan Saragosti, Pascal Silberzan, Axel Buguin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abefea6d77f443218b01775c643f8844
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spelling	oai:doaj.org-article:abefea6d77f443218b01775c643f88442021-11-18T07:21:45ZModeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.1932-620310.1371/journal.pone.0035412https://doaj.org/article/abefea6d77f443218b01775c643f88442012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22530021/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The bacterium Escherichia coli in suspension in a liquid medium swims by a succession of runs and tumbles, effectively describing a random walk. The tumbles randomize incompletely, i.e. with a directional persistence, the orientation taken by the bacterium. Here, we model these tumbles by an active rotational diffusion process characterized by a diffusion coefficient and a diffusion time. In homogeneous media, this description accounts well for the experimental reorientations. In shallow gradients of nutrients, tumbles are still described by a unique rotational diffusion coefficient. Together with an increase in the run length, these tumbles significantly contribute to the net chemotactic drift via a modulation of their duration as a function of the direction of the preceding run. Finally, we discuss the limits of this model in propagating concentration waves characterized by steep gradients. In that case, the effective rotational diffusion coefficient itself varies with the direction of the preceding run. We propose that this effect is related to the number of flagella involved in the reorientation process.Jonathan SaragostiPascal SilberzanAxel BuguinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35412 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jonathan Saragosti Pascal Silberzan Axel Buguin Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.
description	The bacterium Escherichia coli in suspension in a liquid medium swims by a succession of runs and tumbles, effectively describing a random walk. The tumbles randomize incompletely, i.e. with a directional persistence, the orientation taken by the bacterium. Here, we model these tumbles by an active rotational diffusion process characterized by a diffusion coefficient and a diffusion time. In homogeneous media, this description accounts well for the experimental reorientations. In shallow gradients of nutrients, tumbles are still described by a unique rotational diffusion coefficient. Together with an increase in the run length, these tumbles significantly contribute to the net chemotactic drift via a modulation of their duration as a function of the direction of the preceding run. Finally, we discuss the limits of this model in propagating concentration waves characterized by steep gradients. In that case, the effective rotational diffusion coefficient itself varies with the direction of the preceding run. We propose that this effect is related to the number of flagella involved in the reorientation process.
format	article
author	Jonathan Saragosti Pascal Silberzan Axel Buguin
author_facet	Jonathan Saragosti Pascal Silberzan Axel Buguin
author_sort	Jonathan Saragosti
title	Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.
title_short	Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.
title_full	Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.
title_fullStr	Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.
title_full_unstemmed	Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.
title_sort	modeling e. coli tumbles by rotational diffusion. implications for chemotaxis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/abefea6d77f443218b01775c643f8844
work_keys_str_mv	AT jonathansaragosti modelingecolitumblesbyrotationaldiffusionimplicationsforchemotaxis AT pascalsilberzan modelingecolitumblesbyrotationaldiffusionimplicationsforchemotaxis AT axelbuguin modelingecolitumblesbyrotationaldiffusionimplicationsforchemotaxis
_version_	1718423555589275648

Modeling E. coli tumbles by rotational diffusion. Implications for chemotaxis.

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