Excitatory local interneurons enhance tuning of sensory information.

Neurons in the insect antennal lobe represent odors as spatiotemporal patterns of activity that unfold over multiple time scales. As these patterns unspool they decrease the overlap between odor representations and thereby increase the ability of the olfactory system to discriminate odors. Using a r...

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Autores principales:	Collins Assisi, Mark Stopfer, Maxim Bazhenov
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/abf0388439684b9db816eb02d842383c
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spelling	oai:doaj.org-article:abf0388439684b9db816eb02d842383c2021-11-18T05:51:11ZExcitatory local interneurons enhance tuning of sensory information.1553-734X1553-735810.1371/journal.pcbi.1002563https://doaj.org/article/abf0388439684b9db816eb02d842383c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22807661/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Neurons in the insect antennal lobe represent odors as spatiotemporal patterns of activity that unfold over multiple time scales. As these patterns unspool they decrease the overlap between odor representations and thereby increase the ability of the olfactory system to discriminate odors. Using a realistic model of the insect antennal lobe we examined two competing components of this process -lateral excitation from local excitatory interneurons, and slow inhibition from local inhibitory interneurons. We found that lateral excitation amplified differences between representations of similar odors by recruiting projection neurons that did not receive direct input from olfactory receptors. However, this increased sensitivity also amplified noisy variations in input and compromised the ability of the system to respond reliably to multiple presentations of the same odor. Slow inhibition curtailed the spread of projection neuron activity and increased response reliability. These competing influences must be finely balanced in order to decorrelate odor representations.Collins AssisiMark StopferMaxim BazhenovPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 7, p e1002563 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Collins Assisi Mark Stopfer Maxim Bazhenov Excitatory local interneurons enhance tuning of sensory information.
description	Neurons in the insect antennal lobe represent odors as spatiotemporal patterns of activity that unfold over multiple time scales. As these patterns unspool they decrease the overlap between odor representations and thereby increase the ability of the olfactory system to discriminate odors. Using a realistic model of the insect antennal lobe we examined two competing components of this process -lateral excitation from local excitatory interneurons, and slow inhibition from local inhibitory interneurons. We found that lateral excitation amplified differences between representations of similar odors by recruiting projection neurons that did not receive direct input from olfactory receptors. However, this increased sensitivity also amplified noisy variations in input and compromised the ability of the system to respond reliably to multiple presentations of the same odor. Slow inhibition curtailed the spread of projection neuron activity and increased response reliability. These competing influences must be finely balanced in order to decorrelate odor representations.
format	article
author	Collins Assisi Mark Stopfer Maxim Bazhenov
author_facet	Collins Assisi Mark Stopfer Maxim Bazhenov
author_sort	Collins Assisi
title	Excitatory local interneurons enhance tuning of sensory information.
title_short	Excitatory local interneurons enhance tuning of sensory information.
title_full	Excitatory local interneurons enhance tuning of sensory information.
title_fullStr	Excitatory local interneurons enhance tuning of sensory information.
title_full_unstemmed	Excitatory local interneurons enhance tuning of sensory information.
title_sort	excitatory local interneurons enhance tuning of sensory information.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/abf0388439684b9db816eb02d842383c
work_keys_str_mv	AT collinsassisi excitatorylocalinterneuronsenhancetuningofsensoryinformation AT markstopfer excitatorylocalinterneuronsenhancetuningofsensoryinformation AT maximbazhenov excitatorylocalinterneuronsenhancetuningofsensoryinformation
_version_	1718424747844304896

Excitatory local interneurons enhance tuning of sensory information.

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