Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations

Minako Kaido,1,2 Motoko Kawashima,1 Reiko Ishida,1,3 Kazuo Tsubota1 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, 2Wada Eye Clinic, Chiba, 3Ishida Eye Clinic, Shizuoka, Japan Aim: Validating the hypothesis that accommodative microfluctuations (AMFs) may...

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Autores principales:	Kaido M, Kawashima M, Ishida R, Tsubota K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Accommodative microfluctuation Ciliary muscle spasm Dry eye Ocular fatigue Tears: Breakup time Visual acuity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/abf30cd6505b4de996e45aee6a51b033
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spelling	oai:doaj.org-article:abf30cd6505b4de996e45aee6a51b0332021-12-02T06:09:19ZSevere symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations1177-5483https://doaj.org/article/abf30cd6505b4de996e45aee6a51b0332017-05-01T00:00:00Zhttps://www.dovepress.com/severe-symptoms-of-short-tear-break-up-time-dry-eye-are-associated-wit-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Minako Kaido,1,2 Motoko Kawashima,1 Reiko Ishida,1,3 Kazuo Tsubota1 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, 2Wada Eye Clinic, Chiba, 3Ishida Eye Clinic, Shizuoka, Japan Aim: Validating the hypothesis that accommodative microfluctuations (AMFs) may be associated with severe symptoms in short tear break-up time (BUT) dry eye (DE). Methods: This study included 12 subjects with short BUT DE (age: 49.6±18.3 years). Diagnoses were performed based on the presence of DE symptoms, BUT ≤5 s, Schirmer score >5 mm, and negative keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA) examinations were conducted before and after DE treatment. The AMF parameters evaluated were: total high-frequency component (HFC), HFC with low accommodation for the task of staring into the distance (HFC1), HFC with high accommodation for deskwork (HFC2). A subjective questionnaire of DE symptoms was also performed. Results: Mean BUT increased from 1.9±2.0 to 6.4±2.5 s after treatment (P<0.05). The mean logarithm of the minimum angle of resolution functional VA significantly improved (from 0.19±0.19 to 0.12±0.17; P<0.05). Mean power spectrum values for total HFC and HFC1 decreased (from 61.3±5.7 to 53.8±6.6 dB and from 62.9±10.5 to 52.4±6.2 dB, respectively; P<0.05), while the mean HFC2 power spectrum values did not differ before and after treatment (P>0.05). Subjective DE symptoms were reduced in nine patients. Conclusion: Along with the improvement of BUT after treatment, DE symptoms diminished and HFC1 and functional VA improved, suggesting that tear film instability is associated with deterioration of functional VA, AMF, and DE symptoms. Keywords: accommodative microfluctuation, ciliary muscle spasm, dry eye, ocular fatigue, tear break-up time, functional visual acuity Kaido MKawashima MIshida RTsubota KDove Medical PressarticleAccommodative microfluctuationCiliary muscle spasmDry eyeOcular fatigueTears: Breakup timeVisual acuityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 861-869 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Accommodative microfluctuation Ciliary muscle spasm Dry eye Ocular fatigue Tears: Breakup time Visual acuity Ophthalmology RE1-994
spellingShingle	Accommodative microfluctuation Ciliary muscle spasm Dry eye Ocular fatigue Tears: Breakup time Visual acuity Ophthalmology RE1-994 Kaido M Kawashima M Ishida R Tsubota K Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
description	Minako Kaido,1,2 Motoko Kawashima,1 Reiko Ishida,1,3 Kazuo Tsubota1 1Department of Ophthalmology, Keio University School of Medicine, Tokyo, 2Wada Eye Clinic, Chiba, 3Ishida Eye Clinic, Shizuoka, Japan Aim: Validating the hypothesis that accommodative microfluctuations (AMFs) may be associated with severe symptoms in short tear break-up time (BUT) dry eye (DE). Methods: This study included 12 subjects with short BUT DE (age: 49.6±18.3 years). Diagnoses were performed based on the presence of DE symptoms, BUT ≤5 s, Schirmer score >5 mm, and negative keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA) examinations were conducted before and after DE treatment. The AMF parameters evaluated were: total high-frequency component (HFC), HFC with low accommodation for the task of staring into the distance (HFC1), HFC with high accommodation for deskwork (HFC2). A subjective questionnaire of DE symptoms was also performed. Results: Mean BUT increased from 1.9±2.0 to 6.4±2.5 s after treatment (P<0.05). The mean logarithm of the minimum angle of resolution functional VA significantly improved (from 0.19±0.19 to 0.12±0.17; P<0.05). Mean power spectrum values for total HFC and HFC1 decreased (from 61.3±5.7 to 53.8±6.6 dB and from 62.9±10.5 to 52.4±6.2 dB, respectively; P<0.05), while the mean HFC2 power spectrum values did not differ before and after treatment (P>0.05). Subjective DE symptoms were reduced in nine patients. Conclusion: Along with the improvement of BUT after treatment, DE symptoms diminished and HFC1 and functional VA improved, suggesting that tear film instability is associated with deterioration of functional VA, AMF, and DE symptoms. Keywords: accommodative microfluctuation, ciliary muscle spasm, dry eye, ocular fatigue, tear break-up time, functional visual acuity
format	article
author	Kaido M Kawashima M Ishida R Tsubota K
author_facet	Kaido M Kawashima M Ishida R Tsubota K
author_sort	Kaido M
title	Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
title_short	Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
title_full	Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
title_fullStr	Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
title_full_unstemmed	Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
title_sort	severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/abf30cd6505b4de996e45aee6a51b033
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_version_	1718400069046108160

Severe symptoms of short tear break-up time dry eye are associated with accommodative microfluctuations

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