A rational blueprint for the design of chemically-controlled protein switches

Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.

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Autores principales:	Sailan Shui, Pablo Gainza, Leo Scheller, Che Yang, Yoichi Kurumida, Stéphane Rosset, Sandrine Georgeon, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Sai T. Reddy, Bruno E. Correia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abf45e9fa38440d9ad04bb724c9f71ce
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spelling	oai:doaj.org-article:abf45e9fa38440d9ad04bb724c9f71ce2021-12-02T18:51:09ZA rational blueprint for the design of chemically-controlled protein switches10.1038/s41467-021-25735-92041-1723https://doaj.org/article/abf45e9fa38440d9ad04bb724c9f71ce2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25735-9https://doaj.org/toc/2041-1723Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.Sailan ShuiPablo GainzaLeo SchellerChe YangYoichi KurumidaStéphane RossetSandrine GeorgeonRaphaël B. Di RobertoRocío Castellanos-RuedaSai T. ReddyBruno E. CorreiaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sailan Shui Pablo Gainza Leo Scheller Che Yang Yoichi Kurumida Stéphane Rosset Sandrine Georgeon Raphaël B. Di Roberto Rocío Castellanos-Rueda Sai T. Reddy Bruno E. Correia A rational blueprint for the design of chemically-controlled protein switches
description	Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches active in cells.
format	article
author	Sailan Shui Pablo Gainza Leo Scheller Che Yang Yoichi Kurumida Stéphane Rosset Sandrine Georgeon Raphaël B. Di Roberto Rocío Castellanos-Rueda Sai T. Reddy Bruno E. Correia
author_facet	Sailan Shui Pablo Gainza Leo Scheller Che Yang Yoichi Kurumida Stéphane Rosset Sandrine Georgeon Raphaël B. Di Roberto Rocío Castellanos-Rueda Sai T. Reddy Bruno E. Correia
author_sort	Sailan Shui
title	A rational blueprint for the design of chemically-controlled protein switches
title_short	A rational blueprint for the design of chemically-controlled protein switches
title_full	A rational blueprint for the design of chemically-controlled protein switches
title_fullStr	A rational blueprint for the design of chemically-controlled protein switches
title_full_unstemmed	A rational blueprint for the design of chemically-controlled protein switches
title_sort	rational blueprint for the design of chemically-controlled protein switches
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abf45e9fa38440d9ad04bb724c9f71ce
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A rational blueprint for the design of chemically-controlled protein switches

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