Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study

Abstract Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated f...

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Autores principales:	Chiara Spironelli, Antonio Maffei, Zaira Romeo, Giulia Piazzon, Giordano Padovan, Gianna Magnolfi, Ilenia Pasini, Francesca Gomez Homen, Graziano Concari, Alessandro Angrilli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abf76f8535b8460cac23d9b92341aa6d
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spelling	oai:doaj.org-article:abf76f8535b8460cac23d9b92341aa6d2021-12-02T14:58:32ZEvidence of language-related left hypofrontality in Major Depression: An EEG Beta band study10.1038/s41598-020-65168-w2045-2322https://doaj.org/article/abf76f8535b8460cac23d9b92341aa6d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-65168-whttps://doaj.org/toc/2045-2322Abstract Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, using language as a probe to test the integrity of large inter- and intra-hemispheric networks and processes. Thirty MDD patients (22 women) and 32 matched controls (HC) were recruited for an EEG recording in resting state and during two linguistic tasks, phonological and semantic. Normalized alpha and beta EEG spectral bands were measured across all three conditions in the two groups. EEG alpha amplitude showed no hemispheric asymmetry, regardless of group, both at rest and during linguistic tasks. During resting state, analysis of EEG beta revealed a lack of hemispheric asymmetry in both groups, but during linguistic tasks, HC exhibited the typical greater left frontal beta activation, whereas MDD patients showed a lack of frontal asymmetry and a significantly lower activation of left frontal sites. In depressed patients, positive affect was negatively correlated with depression levels and positively correlated with left frontal EEG beta amplitude. Language represents the human process that requires the largest level of integration between and within the hemispheres; thus, language asymmetry was a valid probe to test the left frontal alteration encompassing highly impairing psychiatric disorders, such as schizophrenia and MDD. Indeed, these severe diseases are marked by delusions, ruminations, thought disorders, and hallucinations, all of which have a clear linguistic or metalinguistic basis.Chiara SpironelliAntonio MaffeiZaira RomeoGiulia PiazzonGiordano PadovanGianna MagnolfiIlenia PasiniFrancesca Gomez HomenGraziano ConcariAlessandro AngrilliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiara Spironelli Antonio Maffei Zaira Romeo Giulia Piazzon Giordano Padovan Gianna Magnolfi Ilenia Pasini Francesca Gomez Homen Graziano Concari Alessandro Angrilli Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study
description	Abstract Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, using language as a probe to test the integrity of large inter- and intra-hemispheric networks and processes. Thirty MDD patients (22 women) and 32 matched controls (HC) were recruited for an EEG recording in resting state and during two linguistic tasks, phonological and semantic. Normalized alpha and beta EEG spectral bands were measured across all three conditions in the two groups. EEG alpha amplitude showed no hemispheric asymmetry, regardless of group, both at rest and during linguistic tasks. During resting state, analysis of EEG beta revealed a lack of hemispheric asymmetry in both groups, but during linguistic tasks, HC exhibited the typical greater left frontal beta activation, whereas MDD patients showed a lack of frontal asymmetry and a significantly lower activation of left frontal sites. In depressed patients, positive affect was negatively correlated with depression levels and positively correlated with left frontal EEG beta amplitude. Language represents the human process that requires the largest level of integration between and within the hemispheres; thus, language asymmetry was a valid probe to test the left frontal alteration encompassing highly impairing psychiatric disorders, such as schizophrenia and MDD. Indeed, these severe diseases are marked by delusions, ruminations, thought disorders, and hallucinations, all of which have a clear linguistic or metalinguistic basis.
format	article
author	Chiara Spironelli Antonio Maffei Zaira Romeo Giulia Piazzon Giordano Padovan Gianna Magnolfi Ilenia Pasini Francesca Gomez Homen Graziano Concari Alessandro Angrilli
author_facet	Chiara Spironelli Antonio Maffei Zaira Romeo Giulia Piazzon Giordano Padovan Gianna Magnolfi Ilenia Pasini Francesca Gomez Homen Graziano Concari Alessandro Angrilli
author_sort	Chiara Spironelli
title	Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study
title_short	Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study
title_full	Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study
title_fullStr	Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study
title_full_unstemmed	Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study
title_sort	evidence of language-related left hypofrontality in major depression: an eeg beta band study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/abf76f8535b8460cac23d9b92341aa6d
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Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study

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