Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes.

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Autores principales:	Brennan Olson, Xinxia Zhu, Mason A. Norgard, Peter R. Levasseur, John T. Butler, Abigail Buenafe, Kevin G. Burfeind, Katherine A. Michaelis, Katherine R. Pelz, Heike Mendez, Jared Edwards, Stephanie M. Krasnow, Aaron J. Grossberg, Daniel L. Marks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abf8c7f4da7a45d4af0d1631fd583659
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spelling	oai:doaj.org-article:abf8c7f4da7a45d4af0d1631fd5836592021-12-02T18:15:42ZLipocalin 2 mediates appetite suppression during pancreatic cancer cachexia10.1038/s41467-021-22361-32041-1723https://doaj.org/article/abf8c7f4da7a45d4af0d1631fd5836592021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22361-3https://doaj.org/toc/2041-1723Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes.Brennan OlsonXinxia ZhuMason A. NorgardPeter R. LevasseurJohn T. ButlerAbigail BuenafeKevin G. BurfeindKatherine A. MichaelisKatherine R. PelzHeike MendezJared EdwardsStephanie M. KrasnowAaron J. GrossbergDaniel L. MarksNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brennan Olson Xinxia Zhu Mason A. Norgard Peter R. Levasseur John T. Butler Abigail Buenafe Kevin G. Burfeind Katherine A. Michaelis Katherine R. Pelz Heike Mendez Jared Edwards Stephanie M. Krasnow Aaron J. Grossberg Daniel L. Marks Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
description	Lipocalin 2 (LCN2) has been recently identified as an endogenous regulator of appetite. Here, using pancreatic cancer as a model of cachexia, the authors demonstrate that LCN2 is a critical mediator of cancer-associated anorexia and may be therapeutically targeted to improve patient outcomes.
format	article
author	Brennan Olson Xinxia Zhu Mason A. Norgard Peter R. Levasseur John T. Butler Abigail Buenafe Kevin G. Burfeind Katherine A. Michaelis Katherine R. Pelz Heike Mendez Jared Edwards Stephanie M. Krasnow Aaron J. Grossberg Daniel L. Marks
author_facet	Brennan Olson Xinxia Zhu Mason A. Norgard Peter R. Levasseur John T. Butler Abigail Buenafe Kevin G. Burfeind Katherine A. Michaelis Katherine R. Pelz Heike Mendez Jared Edwards Stephanie M. Krasnow Aaron J. Grossberg Daniel L. Marks
author_sort	Brennan Olson
title	Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
title_short	Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
title_full	Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
title_fullStr	Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
title_full_unstemmed	Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
title_sort	lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abf8c7f4da7a45d4af0d1631fd583659
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Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

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