The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings

Emine Sen,1 Ufuk Elgin,1 Osman Ozen,2 Fikriye Gozde Ozturk3 1University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Glaucoma Department, Ankara, Turkey; 2University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; 3Unye State Hospital, Ordu, T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sen E, Elgin U, Ozen O, Ozturk FG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bleb morphology glaucoma schirmer test trabeculectomy trehalose Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/abf97af0744748ffa21d901c9fb17bd8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:abf97af0744748ffa21d901c9fb17bd8
record_format	dspace
spelling	oai:doaj.org-article:abf97af0744748ffa21d901c9fb17bd82021-12-02T17:21:57ZThe Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings1177-5483https://doaj.org/article/abf97af0744748ffa21d901c9fb17bd82021-06-01T00:00:00Zhttps://www.dovepress.com/the-efficacy-and-safety-of-trehalose-in-primary-trabeculectomy-with-mi-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Emine Sen,1 Ufuk Elgin,1 Osman Ozen,2 Fikriye Gozde Ozturk3 1University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Glaucoma Department, Ankara, Turkey; 2University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; 3Unye State Hospital, Ordu, TurkeyCorrespondence: Emine SenUniversity of Health Sciences, Ulucanlar Eye Education and Research Hospital, Kale Mahallesi, Ulucanlar Caddesi, No: 59, Altındağ, 06250, Ankara, TurkeyTel +90 505 2438124Fax +90 312 3124827Email eminesentr@yahoo.comObjective: To compare bleb morphology and tear tests of glaucoma patients who used trehalose and those who did not use after primary trabeculectomy with mitomycin C (MMC) during the early post-operative period.Methods: This retrospective study included two groups: Group 1 using Trehalose + hyaluronic acid (THA) after primary trabeculectomy with MMC (n = 19) and Group 2 undergoing primary trabeculectomy with MMC (n = 16). The preoperative and postoperative intraocular pressure (IOP), the results of Schirmer, and tear break-up time tests were analyzed. Postoperative bleb morphology was also evaluated at the 1st day, and 1st and 2nd weeks, and 1st and 2nd months.Results: There was no statistically significant difference in preoperative IOP, Schirmer test or tear break-up time between groups. The mean horizontal extent of the blebs was significantly wider in Group 1 at the first week (p= 0.02). Bleb vascularization was also found to be lower in Group 1 at the second week (p= 0.001). The mean bleb height and horizontal extent were significantly higher in Group 1 at the first month (p=0.02, p= 0.03, respectively). The mean bleb horizontal extent was significantly higher in Group 1 at the second month (p= 0.03).Conclusion: The use of trehalose improved surgical success of primary trabeculectomy with MMC in terms of IOP control, post-operative complications, and bleb morphology during the early postoperative period. Trehalose might contribute to wound healing which led to an ideal bleb.Keywords: bleb morphology, glaucoma, Schirmer test, trabeculectomy, trehaloseSen EElgin UOzen OOzturk FGDove Medical Pressarticlebleb morphologyglaucomaschirmer testtrabeculectomytrehaloseOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2301-2306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bleb morphology glaucoma schirmer test trabeculectomy trehalose Ophthalmology RE1-994
spellingShingle	bleb morphology glaucoma schirmer test trabeculectomy trehalose Ophthalmology RE1-994 Sen E Elgin U Ozen O Ozturk FG The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings
description	Emine Sen,1 Ufuk Elgin,1 Osman Ozen,2 Fikriye Gozde Ozturk3 1University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Glaucoma Department, Ankara, Turkey; 2University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey; 3Unye State Hospital, Ordu, TurkeyCorrespondence: Emine SenUniversity of Health Sciences, Ulucanlar Eye Education and Research Hospital, Kale Mahallesi, Ulucanlar Caddesi, No: 59, Altındağ, 06250, Ankara, TurkeyTel +90 505 2438124Fax +90 312 3124827Email eminesentr@yahoo.comObjective: To compare bleb morphology and tear tests of glaucoma patients who used trehalose and those who did not use after primary trabeculectomy with mitomycin C (MMC) during the early post-operative period.Methods: This retrospective study included two groups: Group 1 using Trehalose + hyaluronic acid (THA) after primary trabeculectomy with MMC (n = 19) and Group 2 undergoing primary trabeculectomy with MMC (n = 16). The preoperative and postoperative intraocular pressure (IOP), the results of Schirmer, and tear break-up time tests were analyzed. Postoperative bleb morphology was also evaluated at the 1st day, and 1st and 2nd weeks, and 1st and 2nd months.Results: There was no statistically significant difference in preoperative IOP, Schirmer test or tear break-up time between groups. The mean horizontal extent of the blebs was significantly wider in Group 1 at the first week (p= 0.02). Bleb vascularization was also found to be lower in Group 1 at the second week (p= 0.001). The mean bleb height and horizontal extent were significantly higher in Group 1 at the first month (p=0.02, p= 0.03, respectively). The mean bleb horizontal extent was significantly higher in Group 1 at the second month (p= 0.03).Conclusion: The use of trehalose improved surgical success of primary trabeculectomy with MMC in terms of IOP control, post-operative complications, and bleb morphology during the early postoperative period. Trehalose might contribute to wound healing which led to an ideal bleb.Keywords: bleb morphology, glaucoma, Schirmer test, trabeculectomy, trehalose
format	article
author	Sen E Elgin U Ozen O Ozturk FG
author_facet	Sen E Elgin U Ozen O Ozturk FG
author_sort	Sen E
title	The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings
title_short	The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings
title_full	The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings
title_fullStr	The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings
title_full_unstemmed	The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings
title_sort	efficacy and safety of trehalose in primary trabeculectomy with mitomycin c: a report of early findings
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/abf97af0744748ffa21d901c9fb17bd8
work_keys_str_mv	AT sene theefficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT elginu theefficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT ozeno theefficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT ozturkfg theefficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT sene efficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT elginu efficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT ozeno efficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings AT ozturkfg efficacyandsafetyoftrehaloseinprimarytrabeculectomywithmitomycincareportofearlyfindings
_version_	1718381044495810560

The Efficacy and Safety of Trehalose in Primary Trabeculectomy with Mitomycin C: A Report of Early Findings

Ejemplares similares