A novel olfactory threshold test for screening cognitive decline among elderly people.

Olfactory impairment is associated with dementia and is a potential early biomarker of cognitive decline. We developed a novel olfactory threshold test called Sniff Bubble using rose odor-containing beads made with 2-phenylethyl alcohol. We aimed to define cut-off scores for this tool to help identi...

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Autores principales:	Sun Mi Kim, Hye Ri Kim, Hyun Jin Min, Kyung Soo Kim, Jae-Chan Jin, Doug Hyun Han
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abfab32322ef41a2b724112dd84f6bb9
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spelling	oai:doaj.org-article:abfab32322ef41a2b724112dd84f6bb92021-12-02T20:09:17ZA novel olfactory threshold test for screening cognitive decline among elderly people.1932-620310.1371/journal.pone.0254357https://doaj.org/article/abfab32322ef41a2b724112dd84f6bb92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254357https://doaj.org/toc/1932-6203Olfactory impairment is associated with dementia and is a potential early biomarker of cognitive decline. We developed a novel olfactory threshold test called Sniff Bubble using rose odor-containing beads made with 2-phenylethyl alcohol. We aimed to define cut-off scores for this tool to help identify cognitive decline among elderly people. In total, 162 elderly people (mean age ± SD: 73.04 ± 8.73 years) were administered olfactory threshold and neurocognitive tests. For analyses, we divided the participants into two groups based on cognitive functioning, namely cognitive decline (n = 44) and normal cognition (n = 118) groups. The Sniff Bubble and YSK olfactory function test for olfactory threshold and the Structured Clinical Interview for DSM-5 Disorders-Clinician Version and Korean version of the Consortium to Establish a Registry for Alzheimer's Disease assessment packet for neurocognitive functioning were used. We used K-means cluster analyses and receiver operating characteristic (ROC) analyses to identify the most appropriate cut-off value. We established a positive correlation between the Sniff Bubble and neurocognitive function test scores (r = 0.431, p < 0.001). We defined the cut-off score, using the ROC curve analyses for Sniff Bubble scores, at 3 and higher with an area under the curve of 0.759 (p < 0.001). The Sniff Bubble test can adequately detect cognitive decline in elderly people and may be used clinically as the first step in the screening process.Sun Mi KimHye Ri KimHyun Jin MinKyung Soo KimJae-Chan JinDoug Hyun HanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254357 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sun Mi Kim Hye Ri Kim Hyun Jin Min Kyung Soo Kim Jae-Chan Jin Doug Hyun Han A novel olfactory threshold test for screening cognitive decline among elderly people.
description	Olfactory impairment is associated with dementia and is a potential early biomarker of cognitive decline. We developed a novel olfactory threshold test called Sniff Bubble using rose odor-containing beads made with 2-phenylethyl alcohol. We aimed to define cut-off scores for this tool to help identify cognitive decline among elderly people. In total, 162 elderly people (mean age ± SD: 73.04 ± 8.73 years) were administered olfactory threshold and neurocognitive tests. For analyses, we divided the participants into two groups based on cognitive functioning, namely cognitive decline (n = 44) and normal cognition (n = 118) groups. The Sniff Bubble and YSK olfactory function test for olfactory threshold and the Structured Clinical Interview for DSM-5 Disorders-Clinician Version and Korean version of the Consortium to Establish a Registry for Alzheimer's Disease assessment packet for neurocognitive functioning were used. We used K-means cluster analyses and receiver operating characteristic (ROC) analyses to identify the most appropriate cut-off value. We established a positive correlation between the Sniff Bubble and neurocognitive function test scores (r = 0.431, p < 0.001). We defined the cut-off score, using the ROC curve analyses for Sniff Bubble scores, at 3 and higher with an area under the curve of 0.759 (p < 0.001). The Sniff Bubble test can adequately detect cognitive decline in elderly people and may be used clinically as the first step in the screening process.
format	article
author	Sun Mi Kim Hye Ri Kim Hyun Jin Min Kyung Soo Kim Jae-Chan Jin Doug Hyun Han
author_facet	Sun Mi Kim Hye Ri Kim Hyun Jin Min Kyung Soo Kim Jae-Chan Jin Doug Hyun Han
author_sort	Sun Mi Kim
title	A novel olfactory threshold test for screening cognitive decline among elderly people.
title_short	A novel olfactory threshold test for screening cognitive decline among elderly people.
title_full	A novel olfactory threshold test for screening cognitive decline among elderly people.
title_fullStr	A novel olfactory threshold test for screening cognitive decline among elderly people.
title_full_unstemmed	A novel olfactory threshold test for screening cognitive decline among elderly people.
title_sort	novel olfactory threshold test for screening cognitive decline among elderly people.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/abfab32322ef41a2b724112dd84f6bb9
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A novel olfactory threshold test for screening cognitive decline among elderly people.

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