Functionalized Graphene Platforms for Anticancer Drug Delivery

Shabnam Sattari, Mohsen Adeli, Siamak Beyranvand, Mohammad Nemati Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, IranCorrespondence: Mohsen Adeli Email adeli.m@lu.ac.irAbstract: Two-dimensional nanomaterials are emerging as promising candidates for a wide range of bio...

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Autores principales:	Sattari S, Adeli M, Beyranvand S, Nemati M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	two-dimensional nanomaterials graphene functionalization anticancer drug delivery photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/abfd18e81af348f1a3715a8fbe8906f0
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spelling	oai:doaj.org-article:abfd18e81af348f1a3715a8fbe8906f02021-12-02T16:39:03ZFunctionalized Graphene Platforms for Anticancer Drug Delivery1178-2013https://doaj.org/article/abfd18e81af348f1a3715a8fbe8906f02021-08-01T00:00:00Zhttps://www.dovepress.com/functionalized-graphene-platforms-for-anticancer-drug-delivery-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Shabnam Sattari, Mohsen Adeli, Siamak Beyranvand, Mohammad Nemati Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, IranCorrespondence: Mohsen Adeli Email adeli.m@lu.ac.irAbstract: Two-dimensional nanomaterials are emerging as promising candidates for a wide range of biomedical applications including tissue engineering, biosensing, pathogen incapacitation, wound healing, and gene and drug delivery. Graphene, due to its high surface area, photothermal property, high loading capacity, and efficient cellular uptake, is at the forefront of these materials and plays a key role in this multidisciplinary research field. Poor water dispersibility and low functionality of graphene, however, hamper its hybridization into new nanostructures for future nanomedicine. Functionalization of graphene, either by covalent or non-covalent methods, is the most useful strategy to improve its dispersion in water and functionality as well as processability into new materials and devices. In this review, recent advances in functionalization of graphene derivatives by different (macro)molecules for future biomedical applications are reported and explained. In particular, hydrophilic functionalization of graphene and graphene oxide (GO) to improve their water dispersibility and physicochemical properties is discussed. We have focused on the anticancer drug delivery of polyfunctional graphene sheets.Keywords: two-dimensional nanomaterials, graphene, functionalization, anticancer drug delivery, photothermal therapySattari SAdeli MBeyranvand SNemati MDove Medical Pressarticletwo-dimensional nanomaterialsgraphenefunctionalizationanticancer drug deliveryphotothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 5955-5980 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	two-dimensional nanomaterials graphene functionalization anticancer drug delivery photothermal therapy Medicine (General) R5-920
spellingShingle	two-dimensional nanomaterials graphene functionalization anticancer drug delivery photothermal therapy Medicine (General) R5-920 Sattari S Adeli M Beyranvand S Nemati M Functionalized Graphene Platforms for Anticancer Drug Delivery
description	Shabnam Sattari, Mohsen Adeli, Siamak Beyranvand, Mohammad Nemati Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, IranCorrespondence: Mohsen Adeli Email adeli.m@lu.ac.irAbstract: Two-dimensional nanomaterials are emerging as promising candidates for a wide range of biomedical applications including tissue engineering, biosensing, pathogen incapacitation, wound healing, and gene and drug delivery. Graphene, due to its high surface area, photothermal property, high loading capacity, and efficient cellular uptake, is at the forefront of these materials and plays a key role in this multidisciplinary research field. Poor water dispersibility and low functionality of graphene, however, hamper its hybridization into new nanostructures for future nanomedicine. Functionalization of graphene, either by covalent or non-covalent methods, is the most useful strategy to improve its dispersion in water and functionality as well as processability into new materials and devices. In this review, recent advances in functionalization of graphene derivatives by different (macro)molecules for future biomedical applications are reported and explained. In particular, hydrophilic functionalization of graphene and graphene oxide (GO) to improve their water dispersibility and physicochemical properties is discussed. We have focused on the anticancer drug delivery of polyfunctional graphene sheets.Keywords: two-dimensional nanomaterials, graphene, functionalization, anticancer drug delivery, photothermal therapy
format	article
author	Sattari S Adeli M Beyranvand S Nemati M
author_facet	Sattari S Adeli M Beyranvand S Nemati M
author_sort	Sattari S
title	Functionalized Graphene Platforms for Anticancer Drug Delivery
title_short	Functionalized Graphene Platforms for Anticancer Drug Delivery
title_full	Functionalized Graphene Platforms for Anticancer Drug Delivery
title_fullStr	Functionalized Graphene Platforms for Anticancer Drug Delivery
title_full_unstemmed	Functionalized Graphene Platforms for Anticancer Drug Delivery
title_sort	functionalized graphene platforms for anticancer drug delivery
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/abfd18e81af348f1a3715a8fbe8906f0
work_keys_str_mv	AT sattaris functionalizedgrapheneplatformsforanticancerdrugdelivery AT adelim functionalizedgrapheneplatformsforanticancerdrugdelivery AT beyranvands functionalizedgrapheneplatformsforanticancerdrugdelivery AT nematim functionalizedgrapheneplatformsforanticancerdrugdelivery
_version_	1718383591738572800

Functionalized Graphene Platforms for Anticancer Drug Delivery

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