Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

Abstract Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health an...

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Autores principales:	Na-Kyung Oh, Yun-Mi Song, Shin-Hye Kim, Mi Jung Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac0209fa0fb14d54a642dd9669a21ea6
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spelling	oai:doaj.org-article:ac0209fa0fb14d54a642dd9669a21ea62021-12-02T15:07:53ZShort Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults10.1038/s41598-019-50524-22045-2322https://doaj.org/article/ac0209fa0fb14d54a642dd9669a21ea62019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50524-2https://doaj.org/toc/2045-2322Abstract Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutrition Examination Survey from 2007 to 2015, from 37,889 individuals (aged 12–59 years). In adolescents, total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels had profound associations with height in both boys and girls, while high density lipoprotein-cholesterol (HDL-C) levels had an inverse association with height only in boys. Height was inversely associated with TC, triglycerides (TG), and LDL-C concentrations in men and women and positively correlated with HDL-C concentration in women. In boys, the odds ratios (ORs) for hypercholesterolemia, hypertriglyceridemia, hyper-LDL-cholesterolemia were higher for shorter subjects (ORs = 2.38~7.01), while only the OR of hyper-LDL-cholesterolemia was significantly higher in girls with short stature (OR = 3.12). In adults, the ORs for hypercholesterolemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were significantly higher in short subjects than in tall subjects after controlling for covariates (ORs = 1.50~2.61). Also, short men showed significantly higher ORs for hypertriglyceridemia (OR = 1.85) than tall men. Short stature was significantly associated with adverse lipid profiles in both adolescents and adults.Na-Kyung OhYun-Mi SongShin-Hye KimMi Jung ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Na-Kyung Oh Yun-Mi Song Shin-Hye Kim Mi Jung Park Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
description	Abstract Adults with short stature have been previously reported to have increased risk of cardiovascular events and hyper-LDL-cholesterolemia. We aimed to assess the association between height and lipid profiles among Korean adolescents and adults. We analyzed data from the Korea National Health and Nutrition Examination Survey from 2007 to 2015, from 37,889 individuals (aged 12–59 years). In adolescents, total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels had profound associations with height in both boys and girls, while high density lipoprotein-cholesterol (HDL-C) levels had an inverse association with height only in boys. Height was inversely associated with TC, triglycerides (TG), and LDL-C concentrations in men and women and positively correlated with HDL-C concentration in women. In boys, the odds ratios (ORs) for hypercholesterolemia, hypertriglyceridemia, hyper-LDL-cholesterolemia were higher for shorter subjects (ORs = 2.38~7.01), while only the OR of hyper-LDL-cholesterolemia was significantly higher in girls with short stature (OR = 3.12). In adults, the ORs for hypercholesterolemia, hypo-HDL-cholesterolemia, and hyper-LDL-cholesterolemia were significantly higher in short subjects than in tall subjects after controlling for covariates (ORs = 1.50~2.61). Also, short men showed significantly higher ORs for hypertriglyceridemia (OR = 1.85) than tall men. Short stature was significantly associated with adverse lipid profiles in both adolescents and adults.
format	article
author	Na-Kyung Oh Yun-Mi Song Shin-Hye Kim Mi Jung Park
author_facet	Na-Kyung Oh Yun-Mi Song Shin-Hye Kim Mi Jung Park
author_sort	Na-Kyung Oh
title	Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
title_short	Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
title_full	Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
title_fullStr	Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
title_full_unstemmed	Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults
title_sort	short stature is associated with increased risk of dyslipidemia in korean adolescents and adults
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ac0209fa0fb14d54a642dd9669a21ea6
work_keys_str_mv	AT nakyungoh shortstatureisassociatedwithincreasedriskofdyslipidemiainkoreanadolescentsandadults AT yunmisong shortstatureisassociatedwithincreasedriskofdyslipidemiainkoreanadolescentsandadults AT shinhyekim shortstatureisassociatedwithincreasedriskofdyslipidemiainkoreanadolescentsandadults AT mijungpark shortstatureisassociatedwithincreasedriskofdyslipidemiainkoreanadolescentsandadults
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Short Stature is Associated with Increased Risk of Dyslipidemia in Korean Adolescents and Adults

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