The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1.
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or alm...
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oai:doaj.org-article:ac1043867bf5448089991b19aab179072021-11-18T06:59:18ZThe etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1.1932-620310.1371/journal.pone.0016652https://doaj.org/article/ac1043867bf5448089991b19aab179072011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21311761/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.Bjørn A NexøTove ChristensenJette FrederiksenAnné Møller-LarsenAnnette B OturaiPalle VillesenBettina HansenKari K NissenMagdalena J LaskaTrine S PetersenSandra BonnesenAnne HedemandTingting WuXinjie WangXiuqing ZhangTomasz BrudekRomana MaricHelle B SøndergaardFinn SellebjergKlaus BrusgaardAnders L KjeldbjergHenrik B RasmussenAnders L NielsenMette NyegaardThor PetersenAnders D BørglumFinn S PedersenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e16652 (2011) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Bjørn A Nexø Tove Christensen Jette Frederiksen Anné Møller-Larsen Annette B Oturai Palle Villesen Bettina Hansen Kari K Nissen Magdalena J Laska Trine S Petersen Sandra Bonnesen Anne Hedemand Tingting Wu Xinjie Wang Xiuqing Zhang Tomasz Brudek Romana Maric Helle B Søndergaard Finn Sellebjerg Klaus Brusgaard Anders L Kjeldbjerg Henrik B Rasmussen Anders L Nielsen Mette Nyegaard Thor Petersen Anders D Børglum Finn S Pedersen The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. |
| description |
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis. |
| format |
article |
| author |
Bjørn A Nexø Tove Christensen Jette Frederiksen Anné Møller-Larsen Annette B Oturai Palle Villesen Bettina Hansen Kari K Nissen Magdalena J Laska Trine S Petersen Sandra Bonnesen Anne Hedemand Tingting Wu Xinjie Wang Xiuqing Zhang Tomasz Brudek Romana Maric Helle B Søndergaard Finn Sellebjerg Klaus Brusgaard Anders L Kjeldbjerg Henrik B Rasmussen Anders L Nielsen Mette Nyegaard Thor Petersen Anders D Børglum Finn S Pedersen |
| author_facet |
Bjørn A Nexø Tove Christensen Jette Frederiksen Anné Møller-Larsen Annette B Oturai Palle Villesen Bettina Hansen Kari K Nissen Magdalena J Laska Trine S Petersen Sandra Bonnesen Anne Hedemand Tingting Wu Xinjie Wang Xiuqing Zhang Tomasz Brudek Romana Maric Helle B Søndergaard Finn Sellebjerg Klaus Brusgaard Anders L Kjeldbjerg Henrik B Rasmussen Anders L Nielsen Mette Nyegaard Thor Petersen Anders D Børglum Finn S Pedersen |
| author_sort |
Bjørn A Nexø |
| title |
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. |
| title_short |
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. |
| title_full |
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. |
| title_fullStr |
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. |
| title_full_unstemmed |
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. |
| title_sort |
etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus herv-fc1. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/ac1043867bf5448089991b19aab17907 |
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