Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with curative activity in animal models of acute and l...

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Autores principales:	Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e
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spelling	oai:doaj.org-article:ac12d894b82c4ecab2670dd0dcf7314e2021-12-02T15:35:58ZCombining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness10.1038/s41467-019-13522-62041-1723https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13522-6https://doaj.org/toc/2041-1723Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with curative activity in animal models of acute and late stage sleeping sickness.Fabian HulpiaDorien MabilleGustavo D. CampagnaroGabriela SchumannLouis MaesIsabel RoditiAnders HoferHarry P. de KoningGuy CaljonSerge Van CalenberghNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabian Hulpia Dorien Mabille Gustavo D. Campagnaro Gabriela Schumann Louis Maes Isabel Roditi Anders Hofer Harry P. de Koning Guy Caljon Serge Van Calenbergh Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
description	Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with curative activity in animal models of acute and late stage sleeping sickness.
format	article
author	Fabian Hulpia Dorien Mabille Gustavo D. Campagnaro Gabriela Schumann Louis Maes Isabel Roditi Anders Hofer Harry P. de Koning Guy Caljon Serge Van Calenbergh
author_facet	Fabian Hulpia Dorien Mabille Gustavo D. Campagnaro Gabriela Schumann Louis Maes Isabel Roditi Anders Hofer Harry P. de Koning Guy Caljon Serge Van Calenbergh
author_sort	Fabian Hulpia
title	Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
title_short	Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
title_full	Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
title_fullStr	Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
title_full_unstemmed	Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
title_sort	combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e
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Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

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