Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
Li Bao,1,2 Chunjing Yang,1,2 Zhengyuan Shi,1,2 Zhanrong Wang,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Biocharacteristic Profiling for Evaluation of Rational Drug Use, Beijing, Peo...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/ac141a20301a40b4acd68b862d588572 |
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| Sumario: | Li Bao,1,2 Chunjing Yang,1,2 Zhengyuan Shi,1,2 Zhanrong Wang,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Biocharacteristic Profiling for Evaluation of Rational Drug Use, Beijing, People’s Republic of China; 3Department of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Zhanrong WangDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing 100038, People’s Republic of China, Tel +86-10-6392-6405Email dor_j@163.comDechun JiangDepartment of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing 100038, People’s Republic of China, Tel +86-10-6392-6723Email jiangdechun@sina.comBackground: Obesity is a public health problem all over the world, and dietary habits are considered one of the important reasons.Methods: In this study, serum metabolites of mice fed a normal or high-fat diet (HFD) were analyzed using UPLC-QTOF-MS.Results: A significant increase in body weight was noted in HFD mice. The HFD and control groups were significantly different from each other on OPLS-DA scores. The major metabolites contributing to obesity were lipid metabolites (phosphatidylcholines, phosphatidylethanolamine, and lysophosphatidylcholines). In addition, this study revealed that glycerophospholipid metabolism, α-linolenic acid metabolism, and linoleic acid metabolism were related to obesity and obesity-associated diseases.Conclusion: These results can be used to better understand obesity and assess its risk, which will provide new ideas for treatment.Keywords: obesity, serum metabolomics, high-fat diet, UPLC-QTOF-MS technique |
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