Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet

Li Bao,1,2 Chunjing Yang,1,2 Zhengyuan Shi,1,2 Zhanrong Wang,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Biocharacteristic Profiling for Evaluation of Rational Drug Use, Beijing, Peo...

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Autores principales:	Bao L, Yang C, Shi Z, Wang Z, Jiang D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obesity serum metabolomics high fat diet uplc-qtof-ms technique Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ac141a20301a40b4acd68b862d588572
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spelling	oai:doaj.org-article:ac141a20301a40b4acd68b862d5885722021-11-30T18:50:36ZAnalysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet1178-7007https://doaj.org/article/ac141a20301a40b4acd68b862d5885722021-11-01T00:00:00Zhttps://www.dovepress.com/analysis-of-serum-metabolomics-in-obese-mice-induced-by-high-fat-diet-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Li Bao,1,2 Chunjing Yang,1,2 Zhengyuan Shi,1,2 Zhanrong Wang,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Biocharacteristic Profiling for Evaluation of Rational Drug Use, Beijing, People’s Republic of China; 3Department of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Zhanrong WangDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing 100038, People’s Republic of China, Tel +86-10-6392-6405Email dor_j@163.comDechun JiangDepartment of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing 100038, People’s Republic of China, Tel +86-10-6392-6723Email jiangdechun@sina.comBackground: Obesity is a public health problem all over the world, and dietary habits are considered one of the important reasons.Methods: In this study, serum metabolites of mice fed a normal or high-fat diet (HFD) were analyzed using UPLC-QTOF-MS.Results: A significant increase in body weight was noted in HFD mice. The HFD and control groups were significantly different from each other on OPLS-DA scores. The major metabolites contributing to obesity were lipid metabolites (phosphatidylcholines, phosphatidylethanolamine, and lysophosphatidylcholines). In addition, this study revealed that glycerophospholipid metabolism, α-linolenic acid metabolism, and linoleic acid metabolism were related to obesity and obesity-associated diseases.Conclusion: These results can be used to better understand obesity and assess its risk, which will provide new ideas for treatment.Keywords: obesity, serum metabolomics, high-fat diet, UPLC-QTOF-MS techniqueBao LYang CShi ZWang ZJiang DDove Medical Pressarticleobesityserum metabolomicshigh fat dietuplc-qtof-ms techniqueSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4671-4678 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity serum metabolomics high fat diet uplc-qtof-ms technique Specialties of internal medicine RC581-951
spellingShingle	obesity serum metabolomics high fat diet uplc-qtof-ms technique Specialties of internal medicine RC581-951 Bao L Yang C Shi Z Wang Z Jiang D Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
description	Li Bao,1,2 Chunjing Yang,1,2 Zhengyuan Shi,1,2 Zhanrong Wang,3 Dechun Jiang1,2 1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Biocharacteristic Profiling for Evaluation of Rational Drug Use, Beijing, People’s Republic of China; 3Department of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Zhanrong WangDepartment of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing 100038, People’s Republic of China, Tel +86-10-6392-6405Email dor_j@163.comDechun JiangDepartment of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Haidian District, Beijing 100038, People’s Republic of China, Tel +86-10-6392-6723Email jiangdechun@sina.comBackground: Obesity is a public health problem all over the world, and dietary habits are considered one of the important reasons.Methods: In this study, serum metabolites of mice fed a normal or high-fat diet (HFD) were analyzed using UPLC-QTOF-MS.Results: A significant increase in body weight was noted in HFD mice. The HFD and control groups were significantly different from each other on OPLS-DA scores. The major metabolites contributing to obesity were lipid metabolites (phosphatidylcholines, phosphatidylethanolamine, and lysophosphatidylcholines). In addition, this study revealed that glycerophospholipid metabolism, α-linolenic acid metabolism, and linoleic acid metabolism were related to obesity and obesity-associated diseases.Conclusion: These results can be used to better understand obesity and assess its risk, which will provide new ideas for treatment.Keywords: obesity, serum metabolomics, high-fat diet, UPLC-QTOF-MS technique
format	article
author	Bao L Yang C Shi Z Wang Z Jiang D
author_facet	Bao L Yang C Shi Z Wang Z Jiang D
author_sort	Bao L
title	Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
title_short	Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
title_full	Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
title_fullStr	Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
title_full_unstemmed	Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
title_sort	analysis of serum metabolomics in obese mice induced by high-fat diet
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ac141a20301a40b4acd68b862d588572
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Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet

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