Effluent Osteopontin levels reflect the peritoneal solute transport rate

Long-term peritoneal dialysis (PD) is accompanied by low-grade intraperitoneal inflammation and may eventually lead to peritoneal membrane injury with a high solute transport rate and ultrafiltration failure. Osteopontin (OPN) is highly expressed through the stimulation of pro-inflammatory cytokines...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li Jianzhong, Lan Jingjing, Qiao Qing, Shen Lei, Lu Guoyuan
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	peritoneal dialysis osteopontin peritoneal solute transport rate Medicine R
Acceso en línea:	https://doaj.org/article/ac1c28e378d54b2e9455882dea721289
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ac1c28e378d54b2e9455882dea721289
record_format	dspace
spelling	oai:doaj.org-article:ac1c28e378d54b2e9455882dea7212892021-12-05T14:10:54ZEffluent Osteopontin levels reflect the peritoneal solute transport rate2391-546310.1515/med-2021-0302https://doaj.org/article/ac1c28e378d54b2e9455882dea7212892021-06-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0302https://doaj.org/toc/2391-5463Long-term peritoneal dialysis (PD) is accompanied by low-grade intraperitoneal inflammation and may eventually lead to peritoneal membrane injury with a high solute transport rate and ultrafiltration failure. Osteopontin (OPN) is highly expressed through the stimulation of pro-inflammatory cytokines in many cell types. This study aimed to investigate the potential of OPN as a new indicator of peritoneal deterioration. One hundred nine continuous ambulatory PD patients were analyzed. The levels of OPN and IL-6 in peritoneal effluents or serum were analyzed by ELISA kits. The mean effluent OPN concentration was 2.39 ± 1.87 ng/mL. The OPN levels in drained dialysate were correlated with D/P Cr (p < 0.0001, R = 0.54) and D/D0 glucose (p < 0.0001, R = 0.39). Logistic regression analysis showed that the OPN levels in peritoneal effluents were an independent predictive factor for the increased peritoneal solute transport rate (PSTR) obtained by the peritoneal equilibration test (p < 0.001). The area under the receiver operating characteristic curve of OPN was 0.84 (95% CI: 0.75–0.92) in predicting the increased PSTR with a sensitivity of 86% and a specificity of 67%. The joint utilization of effluent OPN with age, effluent IL-6, and serum albumin further increased the specificity (81%). Thus, OPN may be a useful indicator of peritoneal deterioration in patients with PD.Li JianzhongLan JingjingQiao QingShen LeiLu GuoyuanDe Gruyterarticleperitoneal dialysisosteopontinperitoneal solute transport rateMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 847-853 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	peritoneal dialysis osteopontin peritoneal solute transport rate Medicine R
spellingShingle	peritoneal dialysis osteopontin peritoneal solute transport rate Medicine R Li Jianzhong Lan Jingjing Qiao Qing Shen Lei Lu Guoyuan Effluent Osteopontin levels reflect the peritoneal solute transport rate
description	Long-term peritoneal dialysis (PD) is accompanied by low-grade intraperitoneal inflammation and may eventually lead to peritoneal membrane injury with a high solute transport rate and ultrafiltration failure. Osteopontin (OPN) is highly expressed through the stimulation of pro-inflammatory cytokines in many cell types. This study aimed to investigate the potential of OPN as a new indicator of peritoneal deterioration. One hundred nine continuous ambulatory PD patients were analyzed. The levels of OPN and IL-6 in peritoneal effluents or serum were analyzed by ELISA kits. The mean effluent OPN concentration was 2.39 ± 1.87 ng/mL. The OPN levels in drained dialysate were correlated with D/P Cr (p < 0.0001, R = 0.54) and D/D0 glucose (p < 0.0001, R = 0.39). Logistic regression analysis showed that the OPN levels in peritoneal effluents were an independent predictive factor for the increased peritoneal solute transport rate (PSTR) obtained by the peritoneal equilibration test (p < 0.001). The area under the receiver operating characteristic curve of OPN was 0.84 (95% CI: 0.75–0.92) in predicting the increased PSTR with a sensitivity of 86% and a specificity of 67%. The joint utilization of effluent OPN with age, effluent IL-6, and serum albumin further increased the specificity (81%). Thus, OPN may be a useful indicator of peritoneal deterioration in patients with PD.
format	article
author	Li Jianzhong Lan Jingjing Qiao Qing Shen Lei Lu Guoyuan
author_facet	Li Jianzhong Lan Jingjing Qiao Qing Shen Lei Lu Guoyuan
author_sort	Li Jianzhong
title	Effluent Osteopontin levels reflect the peritoneal solute transport rate
title_short	Effluent Osteopontin levels reflect the peritoneal solute transport rate
title_full	Effluent Osteopontin levels reflect the peritoneal solute transport rate
title_fullStr	Effluent Osteopontin levels reflect the peritoneal solute transport rate
title_full_unstemmed	Effluent Osteopontin levels reflect the peritoneal solute transport rate
title_sort	effluent osteopontin levels reflect the peritoneal solute transport rate
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/ac1c28e378d54b2e9455882dea721289
work_keys_str_mv	AT lijianzhong effluentosteopontinlevelsreflecttheperitonealsolutetransportrate AT lanjingjing effluentosteopontinlevelsreflecttheperitonealsolutetransportrate AT qiaoqing effluentosteopontinlevelsreflecttheperitonealsolutetransportrate AT shenlei effluentosteopontinlevelsreflecttheperitonealsolutetransportrate AT luguoyuan effluentosteopontinlevelsreflecttheperitonealsolutetransportrate
_version_	1718371621957271552

Effluent Osteopontin levels reflect the peritoneal solute transport rate

Ejemplares similares