Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia

Abstract Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of C...

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Autores principales:	Catherine A. Morgan, Tracy R. Melzer, Reece P. Roberts, Kristina Wiebels, Henk J. M. M. Mutsaerts, Meg J. Spriggs, John C. Dalrymple-Alford, Tim J. Anderson, Nicholas J. Cutfield, Gerard Deib, Josef Pfeuffer, Donna Rose Addis, Ian J. Kirk, Lynette J. Tippett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ac1ca4472f9c46c8bd930dfcadba90c1
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spelling	oai:doaj.org-article:ac1ca4472f9c46c8bd930dfcadba90c12021-12-05T12:12:20ZSpatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia10.1038/s41598-021-02313-z2045-2322https://doaj.org/article/ac1ca4472f9c46c8bd930dfcadba90c12021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02313-zhttps://doaj.org/toc/2045-2322Abstract Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps as a surrogate for ATT, in volunteers meeting criteria for subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI) and probable Alzheimer’s dementia (AD). Whole-brain pseudo continuous ASL MRI was performed at 3 T in 122 participants (controls = 20, SCD = 44, MCI = 45 and AD = 13) across three sites in New Zealand. From CBF maps that included all grey matter, sCoV progressively increased across each group with increased cognitive deficit. A similar overall trend was found when examining sCoV solely in the temporal lobe. We conclude that sCoV, a simple to compute imaging metric derived from ASL MRI, is sensitive to varying degrees of cognitive changes and supports the view that vascular health contributes to cognitive decline associated with Alzheimer’s disease.Catherine A. MorganTracy R. MelzerReece P. RobertsKristina WiebelsHenk J. M. M. MutsaertsMeg J. SpriggsJohn C. Dalrymple-AlfordTim J. AndersonNicholas J. CutfieldGerard DeibJosef PfeufferDonna Rose AddisIan J. KirkLynette J. TippettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine A. Morgan Tracy R. Melzer Reece P. Roberts Kristina Wiebels Henk J. M. M. Mutsaerts Meg J. Spriggs John C. Dalrymple-Alford Tim J. Anderson Nicholas J. Cutfield Gerard Deib Josef Pfeuffer Donna Rose Addis Ian J. Kirk Lynette J. Tippett Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
description	Abstract Cerebral blood flow (CBF) measured with arterial spin labelling (ASL) magnetic resonance imaging (MRI) reflects cerebral perfusion, related to metabolism, and arterial transit time (ATT), related to vascular health. Our aim was to investigate the spatial coefficient of variation (sCoV) of CBF maps as a surrogate for ATT, in volunteers meeting criteria for subjective cognitive decline (SCD), amnestic mild cognitive impairment (MCI) and probable Alzheimer’s dementia (AD). Whole-brain pseudo continuous ASL MRI was performed at 3 T in 122 participants (controls = 20, SCD = 44, MCI = 45 and AD = 13) across three sites in New Zealand. From CBF maps that included all grey matter, sCoV progressively increased across each group with increased cognitive deficit. A similar overall trend was found when examining sCoV solely in the temporal lobe. We conclude that sCoV, a simple to compute imaging metric derived from ASL MRI, is sensitive to varying degrees of cognitive changes and supports the view that vascular health contributes to cognitive decline associated with Alzheimer’s disease.
format	article
author	Catherine A. Morgan Tracy R. Melzer Reece P. Roberts Kristina Wiebels Henk J. M. M. Mutsaerts Meg J. Spriggs John C. Dalrymple-Alford Tim J. Anderson Nicholas J. Cutfield Gerard Deib Josef Pfeuffer Donna Rose Addis Ian J. Kirk Lynette J. Tippett
author_facet	Catherine A. Morgan Tracy R. Melzer Reece P. Roberts Kristina Wiebels Henk J. M. M. Mutsaerts Meg J. Spriggs John C. Dalrymple-Alford Tim J. Anderson Nicholas J. Cutfield Gerard Deib Josef Pfeuffer Donna Rose Addis Ian J. Kirk Lynette J. Tippett
author_sort	Catherine A. Morgan
title	Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_short	Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_full	Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_fullStr	Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_full_unstemmed	Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia
title_sort	spatial variation of perfusion mri reflects cognitive decline in mild cognitive impairment and early dementia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac1ca4472f9c46c8bd930dfcadba90c1
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Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early dementia

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