Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives
Peptidylarginine deiminases (PADs) are a group of enzymes that catalyze post-translational modifications of proteins by converting arginine residues into citrullines. Among the five members of the PAD family, PAD2 and PAD4 are the most frequently studied because of their abundant expression in immun...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:ac1e002527e449c5bf552420ec1402e22021-11-04T06:44:44ZPeptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives1664-322410.3389/fimmu.2021.761946https://doaj.org/article/ac1e002527e449c5bf552420ec1402e22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.761946/fullhttps://doaj.org/toc/1664-3224Peptidylarginine deiminases (PADs) are a group of enzymes that catalyze post-translational modifications of proteins by converting arginine residues into citrullines. Among the five members of the PAD family, PAD2 and PAD4 are the most frequently studied because of their abundant expression in immune cells. An increasing number of studies have identified PAD2 as an essential factor in the pathogenesis of many diseases. The successes of preclinical research targeting PAD2 highlights the therapeutic potential of PAD2 inhibition, particularly in sepsis and autoimmune diseases. However, the underlying mechanisms by which PAD2 mediates host immunity remain largely unknown. In this review, we will discuss the role of PAD2 in different types of cell death signaling pathways and the related immune disorders contrasted with functions of PAD4, providing novel therapeutic strategies for PAD2-associated pathology.Zhenyu WuZhenyu WuPatrick LiPatrick LiYuzi TianYuzi TianWenlu OuyangWenlu OuyangJessie Wai-Yan HoHasan B. AlamYongqing LiFrontiers Media S.A.articlePAD2autoimmune diseasessepsisNETosispyroptosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
PAD2 autoimmune diseases sepsis NETosis pyroptosis Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
PAD2 autoimmune diseases sepsis NETosis pyroptosis Immunologic diseases. Allergy RC581-607 Zhenyu Wu Zhenyu Wu Patrick Li Patrick Li Yuzi Tian Yuzi Tian Wenlu Ouyang Wenlu Ouyang Jessie Wai-Yan Ho Hasan B. Alam Yongqing Li Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives |
| description |
Peptidylarginine deiminases (PADs) are a group of enzymes that catalyze post-translational modifications of proteins by converting arginine residues into citrullines. Among the five members of the PAD family, PAD2 and PAD4 are the most frequently studied because of their abundant expression in immune cells. An increasing number of studies have identified PAD2 as an essential factor in the pathogenesis of many diseases. The successes of preclinical research targeting PAD2 highlights the therapeutic potential of PAD2 inhibition, particularly in sepsis and autoimmune diseases. However, the underlying mechanisms by which PAD2 mediates host immunity remain largely unknown. In this review, we will discuss the role of PAD2 in different types of cell death signaling pathways and the related immune disorders contrasted with functions of PAD4, providing novel therapeutic strategies for PAD2-associated pathology. |
| format |
article |
| author |
Zhenyu Wu Zhenyu Wu Patrick Li Patrick Li Yuzi Tian Yuzi Tian Wenlu Ouyang Wenlu Ouyang Jessie Wai-Yan Ho Hasan B. Alam Yongqing Li |
| author_facet |
Zhenyu Wu Zhenyu Wu Patrick Li Patrick Li Yuzi Tian Yuzi Tian Wenlu Ouyang Wenlu Ouyang Jessie Wai-Yan Ho Hasan B. Alam Yongqing Li |
| author_sort |
Zhenyu Wu |
| title |
Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives |
| title_short |
Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives |
| title_full |
Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives |
| title_fullStr |
Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives |
| title_full_unstemmed |
Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and Perspectives |
| title_sort |
peptidylarginine deiminase 2 in host immunity: current insights and perspectives |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/ac1e002527e449c5bf552420ec1402e2 |
| work_keys_str_mv |
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