Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites

Unintended pregnancy is a situation that every woman may encounter, and medical abortion is the first choice for women, but abortion often brings many sequelae. Angelica sinensis Radix (Danggui) and Leonuri Herba (Yimucao) are widely used in the treatment of gynecological diseases, which can regulat...

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Autores principales:	Shi-Jie Bi, Shi-Jun Yue, Xue Bai, Li-Mei Feng, Ding-Qiao Xu, Rui-Jia Fu, Sai Zhang, Yu-Ping Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Danggui Yimucao medical abortion Th1 Th2 metabonomics Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ac208cc0715947848da42d6a2e1a4dc5
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id	oai:doaj.org-article:ac208cc0715947848da42d6a2e1a4dc5
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spelling	oai:doaj.org-article:ac208cc0715947848da42d6a2e1a4dc52021-11-18T06:33:00ZDanggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites1663-981210.3389/fphar.2021.754125https://doaj.org/article/ac208cc0715947848da42d6a2e1a4dc52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.754125/fullhttps://doaj.org/toc/1663-9812Unintended pregnancy is a situation that every woman may encounter, and medical abortion is the first choice for women, but abortion often brings many sequelae. Angelica sinensis Radix (Danggui) and Leonuri Herba (Yimucao) are widely used in the treatment of gynecological diseases, which can regulate menstrual disorders, amenorrhea, dysmenorrhea, and promote blood circulation and remove blood stasis, but the mechanism for the treatment of abortion is not clear. We determined the ability of Danggui and Yimucao herb pair (DY) to regulate the Th1/Th2 paradigm by detecting the level of progesterone in the serum and the expression of T-bet and GATA-3 in the spleen and uterus. Then, we detected the level of metabolites in the serum and enriched multiple metabolic pathways. The arachidonic acid pathway can directly regulate the differentiation of Th1/Th2 cells. This may be one of the potential mechanisms of DY in the treatment of abortion.Shi-Jie BiShi-Jun YueXue BaiLi-Mei FengDing-Qiao XuRui-Jia FuSai ZhangYu-Ping TangFrontiers Media S.A.articleDangguiYimucaomedical abortionTh1Th2metabonomicsTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Danggui Yimucao medical abortion Th1 Th2 metabonomics Therapeutics. Pharmacology RM1-950
spellingShingle	Danggui Yimucao medical abortion Th1 Th2 metabonomics Therapeutics. Pharmacology RM1-950 Shi-Jie Bi Shi-Jun Yue Xue Bai Li-Mei Feng Ding-Qiao Xu Rui-Jia Fu Sai Zhang Yu-Ping Tang Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites
description	Unintended pregnancy is a situation that every woman may encounter, and medical abortion is the first choice for women, but abortion often brings many sequelae. Angelica sinensis Radix (Danggui) and Leonuri Herba (Yimucao) are widely used in the treatment of gynecological diseases, which can regulate menstrual disorders, amenorrhea, dysmenorrhea, and promote blood circulation and remove blood stasis, but the mechanism for the treatment of abortion is not clear. We determined the ability of Danggui and Yimucao herb pair (DY) to regulate the Th1/Th2 paradigm by detecting the level of progesterone in the serum and the expression of T-bet and GATA-3 in the spleen and uterus. Then, we detected the level of metabolites in the serum and enriched multiple metabolic pathways. The arachidonic acid pathway can directly regulate the differentiation of Th1/Th2 cells. This may be one of the potential mechanisms of DY in the treatment of abortion.
format	article
author	Shi-Jie Bi Shi-Jun Yue Xue Bai Li-Mei Feng Ding-Qiao Xu Rui-Jia Fu Sai Zhang Yu-Ping Tang
author_facet	Shi-Jie Bi Shi-Jun Yue Xue Bai Li-Mei Feng Ding-Qiao Xu Rui-Jia Fu Sai Zhang Yu-Ping Tang
author_sort	Shi-Jie Bi
title	Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites
title_short	Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites
title_full	Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites
title_fullStr	Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites
title_full_unstemmed	Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites
title_sort	danggui-yimucao herb pair can protect mice from the immune imbalance caused by medical abortion and stabilize the level of serum metabolites
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ac208cc0715947848da42d6a2e1a4dc5
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Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites

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