A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.
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| Formato: | article |
| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/ac213354426e4f05910a41474b6a0b00 |
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oai:doaj.org-article:ac213354426e4f05910a41474b6a0b002021-12-02T17:31:57ZA CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge10.1038/s41467-018-04758-92041-1723https://doaj.org/article/ac213354426e4f05910a41474b6a0b002018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04758-9https://doaj.org/toc/2041-1723The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.Navid MadaniAmy M. PrinciottoLinh MachShilei DingJérémie PrevostJonathan RichardBhavna HoraLaura SutherlandConnie A. ZhaoBrandon P. ConnTodd BradleyM. Anthony MoodyBruno MelilloAndrés FinziBarton F. HaynesAmos B. Smith IIISampa SantraJoseph SodroskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Navid Madani Amy M. Princiotto Linh Mach Shilei Ding Jérémie Prevost Jonathan Richard Bhavna Hora Laura Sutherland Connie A. Zhao Brandon P. Conn Todd Bradley M. Anthony Moody Bruno Melillo Andrés Finzi Barton F. Haynes Amos B. Smith III Sampa Santra Joseph Sodroski A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| description |
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection. |
| format |
article |
| author |
Navid Madani Amy M. Princiotto Linh Mach Shilei Ding Jérémie Prevost Jonathan Richard Bhavna Hora Laura Sutherland Connie A. Zhao Brandon P. Conn Todd Bradley M. Anthony Moody Bruno Melillo Andrés Finzi Barton F. Haynes Amos B. Smith III Sampa Santra Joseph Sodroski |
| author_facet |
Navid Madani Amy M. Princiotto Linh Mach Shilei Ding Jérémie Prevost Jonathan Richard Bhavna Hora Laura Sutherland Connie A. Zhao Brandon P. Conn Todd Bradley M. Anthony Moody Bruno Melillo Andrés Finzi Barton F. Haynes Amos B. Smith III Sampa Santra Joseph Sodroski |
| author_sort |
Navid Madani |
| title |
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_short |
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_full |
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_fullStr |
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_full_unstemmed |
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| title_sort |
cd4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ac213354426e4f05910a41474b6a0b00 |
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| _version_ |
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